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golgi brefeldin A resistant guanine nucleotide exchange factor 1

Summary

Gene Symbol

GBF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

8729

PubChem

8729

Alliance of Genome Resources

HGNC:4181

Annotation

Keyword

Alternative splicing
Charcot-Marie-Tooth disease
Cytoplasm
Disease variant
Golgi apparatus
Guanine-nucleotide releasing factor
Host-virus interaction
Lipid droplet
Lipid-binding
Membrane
Neurodegeneration
Phosphoprotein
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92538

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
cell activation involved in immune response	IMP	22573891
endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP	12047556
post-Golgi vesicle-mediated transport	TAS
Golgi to endosome transport	IMP	23386609

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

metabolic process [inference]

biosynthetic process [inference]

reactive oxygen species biosynthetic process

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

reactive oxygen species biosynthetic process

cellular process [inference]

cell activation [inference]

cell activation involved in immune response

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of monopolar cell polarity

establishment or maintenance of monopolar cell polarity [inference]

establishment of monopolar cell polarity

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport

Golgi to endosome transport

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

reactive oxygen species biosynthetic process

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to endoplasmic reticulum [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

Golgi organization

Golgi disassembly

vesicle organization [inference]

vesicle coating [inference]

Golgi transport vesicle coating [inference]

COPI coating of Golgi vesicle

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

endoplasmic reticulum-Golgi intermediate compartment organization

organelle disassembly [inference]

Golgi disassembly

cellular component disassembly [inference]

organelle disassembly [inference]

Golgi disassembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to endoplasmic reticulum [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport

Golgi to endosome transport

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to endoplasmic reticulum [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of ARF protein signal transduction

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell surface

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of ARF protein signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of ARF protein signal transduction

regulation of cell cycle [inference]

regulation of mitotic cell cycle

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell surface

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
Golgi stack	IEA
cis-Golgi network	IDA	12047556
trans-Golgi network	IDA	23386609
lipid droplet	IEA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

cell leading edge

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying **all 4** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	TAS
protein binding	IPI	17956946 19039328 23572552 31519766 31570497 32296183
phosphatidylinositol-3,4,5-trisphosphate binding	IDA	22573891
phosphatidylinositol-3,5-bisphosphate binding	IDA	22573891

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

guanine nucleotide exchange factor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of ARF protein signal transduction

Displaying **all 5** entries
InterPro
Armadillo-type fold
Mon2/Sec7/BIG1-like, HUS domain
Sec7 domain superfamily
Sec7 domain
Sec7, C-terminal domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110202	Charcot-Marie-Tooth disease dominant intermediate A	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of 91 in total

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Species	Gene ID	Orthologous MAtrix
Propithecus coquereli	105824300	PROCO10580
Microcebus murinus	105874158	MICMU13743
Salmo salar	106576680	SALSA57995
Salmo salar	106606442	SALSA66990
Equus asinus asinus	106837931	EQUAS12293
Sinocyclocheilus grahami	107573980	SINGR100774
Kryptolebias marmoratus	108239162	KRYMA14289
Ictalurus punctatus	108263054	ICTPU26950
Pygocentrus nattereri	108443838	PYGNA02966
Rhinopithecus bieti	108515098	RHIBE03298