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carbonyl reductase 1

Summary

Gene Symbol

CBR1

Aliases

SDR21C1
short chain dehydrogenase/reductase family 21C, member 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

873

HGNC

1548

KEGG Gene ID

hsa:873

PubChem

873

Alliance of Genome Resources

HGNC:1548

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Lipid metabolism
NADP
Oxidoreductase
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384NL53
P16152	15-hydroxyprostaglandin dehydrogenase [NADP(+)] 20-beta-hydroxysteroid dehydrogenase Alcohol dehydrogenase [NAD(P)+] CBR1 NADPH-dependent carbonyl reductase 1 Prostaglandin 9-ketoreductase Prostaglandin-E(2) 9-reductase Short chain dehydrogenase/reductase family 21C member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cyclooxygenase pathway
vitamin K metabolic process	IDA	18449627
glucocorticoid metabolic process	IDA	28878267
positive regulation of reactive oxygen species metabolic process	IDA	19442656
epithelial cell differentiation	IEP	21492153

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

xenobiotic metabolic process

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

glucocorticoid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

vitamin K metabolic process

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

lipid metabolic process [inference]

steroid metabolic process [inference]

glucocorticoid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

glucocorticoid metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

xenobiotic metabolic process

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

vitamin K metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol
extracellular vesicle	HDA	24769233
extracellular exosome	HDA	19056867 19199708 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	19442656
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA	28878267
carbonyl reductase (NADPH) activity	IBA IDA	18449627 1921984
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	IEA
15-hydroxyprostaglandin dehydrogenase (NADP+) activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

aldo-keto reductase (NADP) activity [inference]

alcohol dehydrogenase (NADP+) activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000159228

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00079

Name

carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]

References

11279087

Rhea

RHEA:19257

a secondary alcohol + NADP⁺

H⁺ + a ketone + NADPH

Enzyme

PMID

RHEA:20744

prostaglandin D₂ + NADP⁺

H⁺ + 15-oxoprostaglandin D₂ + NADPH

Enzyme

1.1.1.196

PMID

RHEA:15937

a primary alcohol + NADP⁺

H⁺ + an aldehyde + NADPH

Enzyme

PMID

RHEA:10736

a primary alcohol + NAD⁺

H⁺ + an aldehyde + NADH

Enzyme

PMID

RHEA:11636

prostaglandin E₁ + NADP⁺

H⁺ + 15-oxoprostaglandin E₁ + NADPH

Enzyme

1.1.1.197

PMID

RHEA:24508

prostaglandin F_2α + NADP⁺

H⁺ + NADPH + prostaglandin E₂

Enzyme

1.1.1.189

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **116** in total

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DO ID	Disease Name	Source
DOID:0050424	familial adenomatous polyposis	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET DisGeNET
DOID:0050697	chorioamnionitis	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET DisGeNET DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0060318	acute promyelocytic leukemia	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080324	tuberous sclerosis 1	DisGeNET
DOID:0080409	familial adenomatous polyposis 1	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006790
Gene Name: carbonyl reductase 1

Ortholog

Displaying entries **1 - 10** of 94 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	177888	WB:WBGene00000975
Caenorhabditis elegans	184742	WB:WBGene00008985
Caenorhabditis elegans	184743	WB:WBGene00008986
Caenorhabditis elegans	188051	WB:WBGene00011424
Caenorhabditis elegans	3565013	WB:WBGene00022809
Ciona intestinalis	100182286		CIOIN13116
Callorhinchus milii	103186742		CALMI35345
Callorhinchus milii	103186743		CALMI35347
Latimeria chalumnae	102349061		LATCH19170
Latimeria chalumnae	102367136		LATCH11841

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements