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ADAM metallopeptidase domain 15

Summary

Gene Symbol

ADAM15

Organism

Homo sapiens (human)

External Links

NCBI Gene

8751

PubChem

8751

Alliance of Genome Resources

HGNC:193

Annotation

Keyword

Alternative splicing
Angiogenesis
Cell adhesion
Cell junction
Cleavage on pair of basic residues
Collagen degradation
Cytoplasmic vesicle
Disulfide bond
EGF-like domain
Flagellum
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13444	Metalloprotease RGD disintegrin protein Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 Metargidin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
angiogenesis	IEA
negative regulation of cell-matrix adhesion	IMP	22505472
immune response to tumor cell	IDA	22505472
proteolysis	IBA
apoptotic process	IDA	22505472

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

cardiac epithelial to mesenchymal transition

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

regeneration [inference]

tissue regeneration

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

cardiac epithelial to mesenchymal transition

growth [inference]

developmental growth [inference]

tissue regeneration

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

response to hypobaric hypoxia

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to tumor cell [inference]

immune response to tumor cell

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

response to hypobaric hypoxia

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

response to ketone [inference]

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to oxygen-containing compound [inference]

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

response to ketone [inference]

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell growth

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell growth

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding

regulation of receptor binding [inference]

negative regulation of receptor binding

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding

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GO Term	Evidence Code	PMID
acrosomal vesicle	IEA
extracellular space	IBA
plasma membrane	TAS
adherens junction	IEA
cell surface	IDA	22505472

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	TAS
metalloendopeptidase activity	IBA
integrin binding	IMP	22505472
integrin binding	IBA
protein binding	IPI	10531379 11741929 15280379 16374509 25416956 25825872 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

protein domain specific binding [inference]

SH3 domain binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disintegrin

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 9** entries
InterPro
ADAM, cysteine-rich domain
Disintegrin domain superfamily
Disintegrin domain
Disintegrin, conserved site
EGF-like domain
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Peptidase M12B, propeptide
Reprolysin domain, adamalysin-type

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	101	FB:FBgn0265140
Drosophila melanogaster	8038	FB:FBgn0265140
Drosophila melanogaster	8728	FB:FBgn0265140
Danio rerio	8751	ZFIN:ZDB-GENE-070809-4
Drosophila melanogaster	8754	FB:FBgn0265140
Drosophila melanogaster	8756	FB:FBgn0265140
Drosophila melanogaster	10863	FB:FBgn0265140
Drosophila melanogaster	11085	FB:FBgn0265140
Drosophila melanogaster	11489	FB:FBgn0265140
Mus musculus	11490	ZFIN:ZDB-GENE-070809-4	MOUSE38786

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OrthoDB (Group)

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Acknowledgements