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bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase

Summary

Gene Symbol

arnA

Organism

Pseudomonas aeruginosa PAO1

External Links

NCBI Gene: 878473
PubChem: 878473

Annotation

Keyword

Antibiotic resistance
Lipid A biosynthesis
Lipopolysaccharide biosynthesis
Multifunctional enzyme
NAD
Oxidoreductase
Reference proteome
Transferase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9HY63

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
response to antibiotic
beta-L-Ara4N-lipid A biosynthetic process	ISS	15695810
lipopolysaccharide biosynthetic process
lipid A biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipopolysaccharide biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

lipopolysaccharide biosynthetic process

glycolipid biosynthetic process [inference]

lipooligosaccharide biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipopolysaccharide biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

lipopolysaccharide metabolic process [inference]

lipopolysaccharide biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipopolysaccharide biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

lipopolysaccharide metabolic process [inference]

lipopolysaccharide biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

lipopolysaccharide metabolic process [inference]

lipopolysaccharide biosynthetic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

lipopolysaccharide biosynthetic process

glycolipid biosynthetic process [inference]

lipooligosaccharide biosynthetic process [inference]

lipooligosaccharide metabolic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

lipooligosaccharide biosynthetic process [inference]

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

lipopolysaccharide metabolic process [inference]

lipopolysaccharide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipopolysaccharide biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

lipopolysaccharide biosynthetic process

glycolipid biosynthetic process [inference]

lipooligosaccharide biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

lipopolysaccharide biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

beta-L-Ara4N-lipid A metabolic process [inference]

beta-L-Ara4N-lipid A biosynthetic process

response to stimulus [inference]

response to chemical [inference]

response to antibiotic

Displaying **all 3** entries
GO Term	Evidence Code	PMID
UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity
UDP-glucuronic acid dehydrogenase activity
carboxy-lyase activity

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

UDP-glucuronic acid dehydrogenase activity

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

hydroxymethyl-, formyl- and related transferase activity [inference]

UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Bacteria

Group Name

formyltransferase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
catalytic activity
conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
transferase activity

Displaying **all 7** entries
InterPro
Formyl transferase, C-terminal
Formyl transferase, N-terminal domain superfamily
Formyl transferase, N-terminal
Formyl transferase-like, C-terminal domain superfamily
Methionyl-tRNA formyltransferase, C-terminal domain
Methionyl-tRNA formyltransferase, N-terminal domain
Methionyl-tRNA formyltransferase

Ortholog

Displaying **all 10** entries
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Pseudomonas helleri	45672872	1608996_0:0001ca
Pseudomonas frederiksbergensis	46906671	104087_0:00102c
Pseudomonas corrugata	55643055	47879_0:000164
Pseudomonas tolaasii NCPPB 2192	55847846	564423_0:000aec
Pseudomonas yamanorum	56071936	515393_0:000229
Pseudomonas azotoformans	57373788	47878_0:000dd4
Pseudomonas poae	66759637	200451_0:0000d6
Pseudomonas gessardii	70099990	78544_0:000bed
Pseudomonas fragi	72388635	296_1:00092b
Pseudomonas extremaustralis	78553108	359110_0:000668

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024