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imidazole glycerol phosphate synthase subunit HisF

Summary

Gene Symbol

hisF1

Organism

Pseudomonas aeruginosa PAO1

External Links

NCBI Gene: 878541
PubChem: 878541

Annotation

Keyword

Cytoplasm
Histidine biosynthesis
Lyase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9HU44	IGP synthase cyclase subunit IGP synthase subunit hisF1 ImGP synthase subunit hisF1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
histidine biosynthetic process	ISS	8494895

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm
imidazoleglycerol-phosphate synthase complex	ISS	8494895

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

imidazoleglycerol-phosphate synthase complex

cellular anatomical entity [inference]

cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
imidazoleglycerol-phosphate synthase activity	ISS	8494895
lyase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

imidazoleglycerol-phosphate synthase activity

lyase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Bacteria

Group Name

1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
K: Transcription

Displaying **all 4** entries
Gene Ontology
amino acid biosynthetic process
histidine biosynthetic process
imidazoleglycerol-phosphate synthase activity
lyase activity

Displaying **all 4** entries
InterPro
Aldolase-type TIM barrel
Histidine biosynthesis protein
Histidine biosynthesis, HisF
Ribulose-phosphate binding barrel

Rhea

RHEA:24793

L-glutamine + 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide

H⁺ + L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide

Enzyme

4.3.2.10

PMID

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.4.0

Last updated: December 8, 2025

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