GlyCosmos Portal

Submissions

actinin alpha 2

Summary

Gene Symbol

ACTN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

PubChem

Alliance of Genome Resources

HGNC:164

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Calcium
Cardiomyopathy
Cytoplasm
Disease variant
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P35609	Alpha-actinin skeletal muscle isoform 2 F-actin cross-linking protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
cell adhesion	TAS	10656685
microspike assembly	IDA	12356918
actin cytoskeleton organization	IBA
regulation of membrane potential	IMP	10812072
regulation of apoptotic process	NAS	16807302

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

sarcomere organization

postsynaptic actin cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

muscle cell development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

sarcomere organization

postsynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

plasma membrane bounded cell projection organization [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

muscle cell development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity [inference]

regulation of cation channel activity [inference]

positive regulation of cation channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

regulation of cation channel activity [inference]

positive regulation of cation channel activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

negative regulation of potassium ion transport

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of potassium ion transport

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

regulation of cation channel activity [inference]

positive regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

positive regulation of potassium ion transport

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transport

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

positive regulation of potassium ion transport

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transport

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

regulation of vesicle-mediated transport [inference]

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

negative regulation of protein localization to cell surface

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

positive regulation of potassium ion transport

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transport

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity [inference]

regulation of cation channel activity [inference]

positive regulation of cation channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

regulation of cation channel activity [inference]

positive regulation of cation channel activity

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transporter activity

positive regulation of cation channel activity

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of protein-containing complex disassembly [inference]

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

negative regulation of protein localization to cell surface

regulation of vesicle-mediated transport [inference]

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

regulation of biological quality [inference]

regulation of membrane potential

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity [inference]

regulation of cation channel activity [inference]

positive regulation of cation channel activity

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

negative regulation of molecular function [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

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GO Term	Evidence Code	PMID
extracellular region	TAS
cytosol	TAS
cytoskeleton	NAS	12809483
actin filament	TAS	1339456
plasma membrane	IDA	19815520

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

Z disc

cell junction

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

cell projection

plasma membrane bounded cell projection [inference]

pseudopodium

neuron projection [inference]

neuron spine [inference]

dendritic spine

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton [inference]

postsynaptic actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton [inference]

postsynaptic actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynapse [inference]

dendritic spine

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
integrin binding	TAS	8104223
calcium ion binding	IEA
protein binding	IPI	10427098 10788519 10812072 10861853 11101506 11309420 11389904 11842093 11846417 12559088 12809483 12812986 15205937 15737636 15841212 16902413 19815520 19932097 22972877 23414517 24860983 25416956 25910212 26871637 31413325 31515488 32296183 9501083
phosphatidylinositol-4,5-bisphosphate binding	IDA	25433700
cytoskeletal protein binding	IDA	10427098 11699871

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton [inference]

structural constituent of postsynaptic actin cytoskeleton

structural constituent of muscle

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic actin cytoskeleton

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cytoskeletal protein binding

actin binding [inference]

actin filament binding

protein domain specific binding

cell adhesion molecule binding [inference]

integrin binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

transcription regulator activity [inference]

transcription coregulator activity [inference]

transcription coactivator activity [inference]

nuclear receptor coactivator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

actinin alpha

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
CH domain superfamily
Calponin homology domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050431	arrhythmogenic right ventricular cardiomyopathy	Alliance of Genome Resources
DOID:0081342	congenital myopathy 8	Alliance of Genome Resources
DOID:0110428	dilated cardiomyopathy 1AA	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	81	FB:FBgn0000667
Drosophila melanogaster	87	FB:FBgn0000667
Xenopus tropicalis	88	Xenbase:XB-GENE-489122
Mus musculus	11472	Xenbase:XB-GENE-489122	MOUSE11811
Drosophila melanogaster	11474	FB:FBgn0000667
Drosophila melanogaster	60595	FB:FBgn0000667
Rattus norvegicus	291245		RATNO12077
Pan troglodytes	469156		PANTR23998
Canis lupus familiaris	479191		CANLF14525
Bos taurus	536607		BOVIN22323

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements