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fibroblast growth factor 16

Summary

Gene Symbol

FGF16

Organism

Homo sapiens (human)

External Links

NCBI Gene

8823

PubChem

8823

Alliance of Genome Resources

HGNC:3672

Annotation

Keyword

Disease variant
Glycoprotein
Growth factor
Phosphoprotein
Reference proteome
Secreted

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A7U3L5H2
O43320

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
regulation of endothelial cell proliferation	IDA	16756958
signal transduction	TAS	9473496
cell-cell signaling	TAS	9473496
positive regulation of cell population proliferation	IBA
fibroblast growth factor receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cellular developmental process [inference]

cell differentiation

neurogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

cellular developmental process [inference]

cell differentiation

neurogenesis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to temperature stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

signaling [inference]

cell-cell signaling

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis [inference]

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of cell motility [inference]

regulation of cell migration

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis [inference]

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis [inference]

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of cellular response to growth factor stimulus [inference]

regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

regulation of sprouting angiogenesis

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of cell motility [inference]

regulation of cell migration

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis [inference]

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of endothelial cell chemotaxis [inference]

regulation of endothelial cell chemotaxis to fibroblast growth factor [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

regulation of sprouting angiogenesis

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of transferase activity [inference]

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IBA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
fibroblast growth factor receptor binding	IBA
protein binding	IPI	32296183
growth factor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

growth factor activity

growth factor receptor binding [inference]

fibroblast growth factor receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Fibroblast growth factor 16

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
animal organ morphogenesis
cell differentiation
fibroblast growth factor receptor signaling pathway
growth factor activity
positive regulation of cell division
positive regulation of cell population proliferation
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of gene expression
positive regulation of protein phosphorylation

Displaying **all 2** entries
InterPro
Cytokine IL1/FGF
Fibroblast growth factor family

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111813	syndactyly type 8	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	2248	FB:FBgn0014135
Drosophila melanogaster	2250	FB:FBgn0014135
Drosophila melanogaster	2251	FB:FBgn0014135
Drosophila melanogaster	2252	FB:FBgn0014135
Caenorhabditis elegans	2254	WB:WBGene00002881
Drosophila melanogaster	2255	FB:FBgn0014135
Xenopus tropicalis	8823	Xenbase:XB-GENE-483589
Drosophila melanogaster	14165	FB:FBgn0014135
Drosophila melanogaster	14176	FB:FBgn0014135
Drosophila melanogaster	14177	FB:FBgn0014135

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Acknowledgements