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MIRAGE

bifunctional regulatory protein/DNA repair enzyme AlkA

Summary

Gene Symbol

alkA

Organism

Mycobacterium tuberculosis H37Rv

External Links

NCBI Gene: 886916
PubChem: 886916

Annotation

Keyword

Activator
DNA repair
DNA-binding
Hydrolase
Metal-binding
Methyltransferase
Multifunctional enzyme
Reference proteome
Transcription regulation
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P9WJW3	Regulatory protein AlkA

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
base-excision repair, AP site formation
DNA dealkylation involved in DNA repair
methylation
response to nitrosative stress

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

methylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

response to stimulus [inference]

response to stress [inference]

response to nitrosative stress

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasm
plasma membrane
peptidoglycan-based cell wall
protein-DNA complex

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

external encapsulating structure [inference]

cell wall [inference]

peptidoglycan-based cell wall

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
DNA-binding transcription factor activity
methyltransferase activity
zinc ion binding
DNA-3-methyladenine glycosylase activity
alkylated DNA binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity [inference]

alkylbase DNA N-glycosylase activity [inference]

DNA-3-methylbase glycosylase activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA N-glycosylase activity [inference]

alkylbase DNA N-glycosylase activity [inference]

DNA-3-methylbase glycosylase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding [inference]

alkylated DNA binding

sequence-specific DNA binding

transcription regulator activity [inference]

DNA-binding transcription factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Bacteria

Group Name

hydrolase

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 11 in total

1

2

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Last »
Gene Ontology
DNA dealkylation involved in DNA repair
DNA repair
DNA-3-methyladenine glycosylase activity
DNA-7-methylguanine glycosylase activity
alkylated DNA binding
base-excision repair, AP site formation
base-excision repair
catalytic activity
methylation
response to stress

Displaying **all 2** entries
InterPro
DNA glycosylase
HhH-GPD domain

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025