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cholecystokinin B receptor

Summary

Gene Symbol

CCKBR

Organism

Homo sapiens (human)

External Links

NCBI Gene

887

PubChem

887

Alliance of Genome Resources

HGNC:1571

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Palmitate
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P32239	Cholecystokinin-2 receptor
E9PIC8	Cholecystokinin-2 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
gastric acid secretion	IEA
cell surface receptor signaling pathway	NAS	10913157
phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	7681836
phospholipase C-activating G protein-coupled receptor signaling pathway	IBA
positive regulation of cytosolic calcium ion concentration	IDA	10913157

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

gastric acid secretion

developmental process [inference]

anatomical structure development [inference]

tube development [inference]

digestive tract development

animal organ development [inference]

gland development

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

regulation of pH [inference]

pH reduction

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

acid secretion [inference]

gastric acid secretion

biological regulation [inference]

regulation of pH [inference]

pH reduction

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA
intracellular membrane-bounded organelle	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cholecystokinin receptor activity	IDA	7681836
cholecystokinin receptor activity	IBA
protein binding	IPI	16963136 23597562 25416956
neuropeptide receptor activity	IBA
gastrin receptor activity	IDA	10913157 7681836

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

neuropeptide receptor binding [inference]

cholecystokinin receptor binding [inference]

type B gastrin/cholecystokinin receptor binding

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

kinase regulator activity [inference]

1-phosphatidylinositol-3-kinase regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cholecystokinin A receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:594	panic disorder	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	886	FB:FBgn0030954
Xenopus laevis	887	Xenbase:XB-GENE-22061756
Drosophila melanogaster	12425	FB:FBgn0030954
Mus musculus	12426	ZFIN:ZDB-GENE-060503-482	MOUSE51715
Drosophila melanogaster	24889	FB:FBgn0030954
Rattus norvegicus	25706	FB:FBgn0030954	RATNO21240
Bos taurus	281665		BOVIN06923
Xenopus laevis	378563	Xenbase:XB-GENE-5793825
Pan troglodytes	466414		PANTR02176
Macaca mulatta	712939		MACMU10583

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements