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eukaryotic translation initiation factor 2 subunit beta

Summary

Gene Symbol

EIF2S2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8894

PubChem

8894

Alliance of Genome Resources

HGNC:3266

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Host-virus interaction
Initiation factor
Isopeptide bond
Phosphoprotein
Reference proteome
Ubl conjugation
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P20042	Eukaryotic translation initiation factor 2 subunit beta
Q6IBR8	Eukaryotic translation initiation factor 2 subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
in utero embryonic development	IEA
formation of translation preinitiation complex	IBA
male germ cell proliferation	IEA
cytoplasmic translational initiation	IMP	31836389
translational initiation	IDA	10563826

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular process [inference]

cell population proliferation [inference]

germ cell proliferation [inference]

male germ cell proliferation

cellular process involved in reproduction in multicellular organism [inference]

germ cell proliferation [inference]

male germ cell proliferation

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular process involved in reproduction in multicellular organism [inference]

germ cell proliferation [inference]

male germ cell proliferation

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	12426392
cytoplasm	IDA	12426392
cytosol	TAS
eukaryotic translation initiation factor 2 complex	IDA	23063529
eukaryotic translation initiation factor 2 complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 2 complex

cellular anatomical entity [inference]

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
mRNA binding	IBA
translation initiation factor activity	IDA	16289705
translation initiation factor activity	IBA
protein binding	IPI	11959995 16288713 16932749 21745818 22113938 22813744 25147208 25609649 28514442 32814053 33961781 35271311

GO Hierarchy

molecular function

binding [inference]

protein binding

translation initiation factor binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Translation initiation factor

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
formation of cytoplasmic translation initiation complex
formation of translation preinitiation complex
translation initiation factor binding

Displaying **all 4** entries
InterPro
Translation initiation factor IF2/IF5 domain
Translation initiation factor IF2/IF5, N-terminal
Translation initiation factor IF2/IF5, zinc-binding
Translation initiation factor IF2/IF5

Ortholog

Displaying entries **1 - 10** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8894	Xenbase:XB-GENE-479634
Xenopus tropicalis	43136	Xenbase:XB-GENE-479634
Mus musculus	67204		MOUSE36388
Xenopus tropicalis	160728	Xenbase:XB-GENE-479634
Xenopus tropicalis	216225	Xenbase:XB-GENE-479634
Rattus norvegicus	296302		RATNO28584
Danio rerio	324365		DANRE39148
Xenopus tropicalis	326229	Xenbase:XB-GENE-479634
Xenopus tropicalis	403396	Xenbase:XB-GENE-479634
Pan troglodytes	458188		PANTR24674

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements