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phospholipase C zeta 1

Summary

Gene Symbol

PLCZ1

Aliases

NYD-SP27
PLCzeta

Organism

Homo sapiens (human)

External Links

NCBI Gene

89869

HGNC

19218

KEGG Gene ID

hsa:89869

PubChem

89869

Alliance of Genome Resources

HGNC:19218

JoGo

PLCZ1

TogoVar

PLCZ1

Annotation

Keyword

Alternative splicing
Calcium
Cytoplasm
Developmental protein
Disease variant
Fertilization
Hydrolase
Lipid degradation
Nucleus
Proteomics identification
Reference proteome
Transducer

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VJR9
Q86YW0	Phosphoinositide phospholipase C-zeta-1 Phospholipase C-zeta-1 Testis-development protein NYD-SP27

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
calcium ion transport	IEA
positive regulation of cytosolic calcium ion concentration	IMP	26721930 28270562
egg activation	IMP	26721930
lipid catabolic process	IEA
intracellular signal transduction	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular process [inference]

cell activation [inference]

egg activation

signal transduction [inference]

intracellular signal transduction

reproductive process [inference]

multicellular organismal process [inference]

cell activation [inference]

egg activation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration involved in egg activation

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GO Term	Evidence Code	PMID
nucleus	IDA	18322275
nucleus	IBA
nucleoplasm	IEA
nucleolus	IEA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

pronucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

pronucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol phospholipase C activity	NAS	26116451
phosphatidylinositol phospholipase C activity	IDA	28270562
phosphatidylinositol phospholipase C activity	IBA
calcium ion binding	IEA
phosphatidylinositol-4,5-bisphosphate binding	IDA	28270562

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
lipid metabolic process
metal ion binding
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 8** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phosphoinositide-specific phospholipase C, EF-hand-like domain
Phospholipase C, phosphatidylinositol-specific, Y domain