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transient receptor potential cation channel subfamily A member 1

Summary

Gene Symbol

TRPA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

8989

PubChem

8989

Alliance of Genome Resources

HGNC:497

Annotation

Keyword

3D-structure
ANK repeat
Calcium channel
Cell membrane
Coiled coil
Disease variant
Disulfide bond
Glycoprotein
Hydroxylation
Oxidation
Reference proteome
Repeat
Sensory transduction
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O75762	Ankyrin-like with transmembrane domains protein 1 Transformation-sensitive protein p120 Wasabi receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 18 in total

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GO Term	Evidence Code	PMID
thermoception	IEA
detection of mechanical stimulus involved in sensory perception of pain	IEA
detection of chemical stimulus involved in sensory perception of pain	IEA
protein homotetramerization	IDA	25855297
cellular response to hydrogen peroxide	IDA	30990108

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to food

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

sensory perception of temperature stimulus [inference]

thermoception

multicellular organismal response to stress [inference]

response to pain

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to cold

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

multicellular organismal response to stress [inference]

response to pain

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to food [inference]

cellular response to food

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to organic cyclic compound

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

response to food [inference]

cellular response to food

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to food

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of chemical stimulus [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to food

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IMP	20547126 25855297
stereocilium bundle	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cluster of actin-based cell projections [inference]

stereocilium bundle

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
temperature-gated cation channel activity	IDA	20547126

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

temperature-gated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

temperature-gated ion channel activity [inference]

temperature-gated cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

temperature-gated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

passive transmembrane transporter activity [inference]

channel activity

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

temperature-gated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

temperature-gated ion channel activity [inference]

temperature-gated cation channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

temperature-gated ion channel activity [inference]

temperature-gated cation channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transient receptor potential cation channel

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 3** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Ion transport domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111729	familial episodic pain syndrome 1	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 78 in total

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Species	Gene ID	Orthologous MAtrix
Macaca mulatta	694623	MACMU43998
Monodelphis domestica	100028386	MONDO17282
Equus caballus	100061564	HORSE42871
Ornithorhynchus anatinus	100087634	ORNAN25242
Taeniopygia guttata	100221097	TAEGU18873
Oryctolagus cuniculus	100341337	RABIT09748
Callithrix jacchus	100414472	CALJA14551
Pongo abelii	100460642	PONAB34184
Ailuropoda melanoleuca	100482362	AILME09168
Anolis carolinensis	100556580	ANOCA05522

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements