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kalirin RhoGEF kinase

Summary

Gene Symbol

KALRN

Organism

Homo sapiens (human)

External Links

NCBI Gene

8997

PubChem

8997

Alliance of Genome Resources

HGNC:4814

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Coiled coil
Cytoskeleton
Disulfide bond
Guanine-nucleotide releasing factor
Immunoglobulin domain
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain
Serine/threonine-protein kinase

Proteins

Displaying **all 4** entries
UniProt	Protein Name
O60229	Huntingtin-associated protein-interacting protein Protein Duo Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
A0A804HKT9
A0A804HKJ7
C9IZQ6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
chromatin remodeling	IEA
protein phosphorylation	TAS	10023074
signal transduction	TAS	9285789
nervous system development	ISS
axon guidance	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

intracellular signal transduction

vesicle-mediated transport

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
cytoplasm	IBA
cytosol	TAS
cytosol	IDA
postsynaptic density	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynaptic specialization [inference]

postsynaptic density

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
protein serine/threonine kinase activity	TAS	10023074
3-phosphoinositide-dependent protein kinase activity	IEA
DNA-dependent protein kinase activity	IEA
AMP-activated protein kinase activity	IEA
eukaryotic translation initiation factor 2alpha kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kalirin

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying entries **1 - 10** of 22 in total

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InterPro
CRAL-TRIO lipid binding domain superfamily
CRAL-TRIO lipid binding domain
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:12720	cerebral atherosclerosis	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 58 in total

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Species	Gene ID	Orthologous MAtrix
Nannospalax galili	103741996	NANGA00804
Rhinopithecus roxellana	104655403	RHIRO16741
Esox lucius	105016154	ESOLU46876
Macaca nemestrina	105470260	MACNE19851
Mandrillus leucophaeus	105533177	MANLE06531
Cercocebus atys	105589792	CERAT26693
Aotus nancymaae	105731910	AOTNA36912
Propithecus coquereli	105806497	PROCO00843
Microcebus murinus	105879860	MICMU14199
Dipodomys ordii	105987994	DIPOR09967

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements