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suppressor of cytokine signaling 3

Summary

Gene Symbol

SOCS3

Organism

Homo sapiens (human)

External Links

NCBI Gene

9021

PubChem

9021

Alliance of Genome Resources

HGNC:19391

Annotation

Keyword

Growth regulation
Pharmaceutical
Phosphoprotein
Reference proteome
SH2 domain
Signal transduction inhibitor
Ubl conjugation pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O14543	Cytokine-inducible SH2 protein 3 STAT-induced STAT inhibitor 3
Q6FI39

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein ubiquitination	IEA
cytokine-mediated signaling pathway	IBA
intracellular signal transduction	IEA
negative regulation of apoptotic process	TAS	9266833
positive regulation of cell differentiation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

intracellular signal transduction

cellular developmental process [inference]

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

embryonic morphogenesis [inference]

branching involved in labyrinthine layer morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

anatomical structure development [inference]

blood vessel development [inference]

placenta blood vessel development

cellular developmental process [inference]

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

response to interleukin-17 [inference]

cellular response to interleukin-17

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cytoplasmic side of plasma membrane	IDA	9727029

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phosphotyrosine residue binding	IEA
protein kinase inhibitor activity	TAS	9266833
cytokine receptor binding	IBA
protein binding	IPI	19027008 24728074 25203322 25416956 32296183
protein tyrosine kinase inhibitor activity	IDA	9727029

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding

phosphoprotein binding [inference]

protein phosphorylated amino acid binding [inference]

phosphotyrosine residue binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

regulatory RNA binding [inference]

miRNA binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity

protein tyrosine kinase inhibitor activity

kinase regulator activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity

protein tyrosine kinase inhibitor activity

protein kinase regulator activity [inference]

protein kinase inhibitor activity

protein tyrosine kinase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity

protein tyrosine kinase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Suppressor of cytokine signaling

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
1-phosphatidylinositol-3-kinase regulator activity
protein ubiquitination

Displaying **all 4** entries
InterPro
SH2 domain superfamily
SH2 domain
SOCS box domain
SOCS box-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 86 in total

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Species	Gene ID	Orthologous MAtrix
Takifugu rubripes	778006	TAKRU42726
Monodelphis domestica	100026656	MONDO13891
Equus caballus	100050730	HORSE03725
Ornithorhynchus anatinus	100090302	ORNAN00099
Gasterosteus aculeatus	100192332	GASAC08147
Taeniopygia guttata	100227853	TAEGU07213
Ovis aries	100294595	SHEEP03338
Pongo abelii	100446544	PONAB12290
Ailuropoda melanoleuca	100475555	AILME13637
Ictalurus punctatus	100528984	ICTPU25084

GlyTouCan

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements