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huntingtin interacting protein 1 related

Summary

Gene Symbol

HIP1R

Organism

Homo sapiens (human)

External Links

NCBI Gene

9026

PubChem

9026

Alliance of Genome Resources

HGNC:18415

JoGo

HIP1R

TogoVar

HIP1R

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Coiled coil
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Endocytosis
Membrane
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B3KQW8
O75146	Huntingtin-interacting protein 12
B4DPL0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
endocytosis	IBA
receptor-mediated endocytosis	IMP	11889126
activation of cysteine-type endopeptidase activity involved in apoptotic process
actin filament organization	IBA
regulation of endocytosis	NAS	20074057

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

membrane organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

supramolecular fiber organization [inference]

actin filament organization

postsynapse organization

developmental process [inference]

anatomical structure development [inference]

system development [inference]

digestive system development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

import into cell [inference]

endocytosis

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of gastric acid secretion

positive regulation of transport [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of clathrin-dependent endocytosis

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of transport [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

regulation of clathrin coat assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component organization [inference]

regulation of endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of clathrin-dependent endocytosis

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of mitochondrion organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

regulation of clathrin coat assembly [inference]

positive regulation of clathrin coat assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of clathrin-dependent endocytosis

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

regulation of gastric acid secretion

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of membrane permeability [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of binding [inference]

positive regulation of protein binding

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding

positive regulation of binding [inference]

positive regulation of protein binding

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
mitochondrion	IEA
cytosol	TAS
cytosol	IDA
plasma membrane	IDA
clathrin-coated pit	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

bounding membrane of organelle [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

synaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

postsynapse [inference]

dendritic spine

postsynaptic endocytic zone

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11889126 19255499 32296183
phosphatidylinositol-4,5-bisphosphate binding	IDA	14732715
phosphatidylinositol-3,4,5-trisphosphate binding	IDA	14732715
SH3 domain binding	IEA
clathrin binding	IDA	14732715

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

protein domain specific binding [inference]

SH3 domain binding

clathrin binding

clathrin light chain binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

phosphatidylinositol bisphosphate binding [inference]

ion binding [inference]

anion binding [inference]

protein-containing complex binding [inference]

actin filament binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

cargo adaptor activity [inference]

clathrin adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

huntingtin interacting protein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
actin binding
actin filament binding
actin filament organization
clathrin adaptor activity
clathrin binding
clathrin coat assembly
clathrin light chain binding
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-3,5-bisphosphate binding
phospholipid binding

Displaying **all 7** entries
InterPro
AP180 N-terminal homology (ANTH) domain
ENTH domain
ENTH/VHS
Huntingtin-interacting protein 1, clathrin-binding domain
I/LWEQ domain superfamily
I/LWEQ domain
Sla2 family

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements