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huntingtin interacting protein 1 related

Summary

Gene Symbol

HIP1R

Organism

Homo sapiens (human)

External Links

NCBI Gene

9026

PubChem

9026

Alliance of Genome Resources

HGNC:18415

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Coiled coil
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Endocytosis
Membrane
Phosphoprotein
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B3KQW8
B4DPL0
O75146	Huntingtin-interacting protein 12

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
endocytosis	IBA
receptor-mediated endocytosis	IMP	11889126
activation of cysteine-type endopeptidase activity involved in apoptotic process
actin filament organization	IBA
regulation of endocytosis	NAS	20074057

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

membrane organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

supramolecular fiber organization [inference]

actin filament organization

postsynapse organization

developmental process [inference]

anatomical structure development [inference]

system development [inference]

digestive system development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

import into cell [inference]

endocytosis

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of gastric acid secretion

positive regulation of transport [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of clathrin-dependent endocytosis

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of transport [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

regulation of clathrin coat assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component organization [inference]

regulation of endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of clathrin-dependent endocytosis

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of mitochondrion organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

regulation of clathrin coat assembly [inference]

positive regulation of clathrin coat assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of protein-containing complex assembly [inference]

positive regulation of clathrin coat assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of clathrin-dependent endocytosis

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

regulation of gastric acid secretion

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of membrane permeability [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of binding [inference]

positive regulation of protein binding

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding

positive regulation of binding [inference]

positive regulation of protein binding

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
mitochondrion	IEA
cytosol	TAS
cytosol	IDA
plasma membrane	IDA
clathrin-coated pit	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

bounding membrane of organelle [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

synaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

postsynapse [inference]

dendritic spine

postsynaptic endocytic zone

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11889126 19255499 32296183
phosphatidylinositol-4,5-bisphosphate binding	IDA	14732715
phosphatidylinositol-3,4,5-trisphosphate binding	IDA	14732715
SH3 domain binding	IEA
clathrin binding	IDA	14732715

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

protein domain specific binding [inference]

SH3 domain binding

clathrin binding

clathrin light chain binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

phosphatidylinositol bisphosphate binding [inference]

ion binding [inference]

anion binding [inference]

protein-containing complex binding [inference]

actin filament binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

cargo adaptor activity [inference]

clathrin adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

huntingtin interacting protein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
actin binding
actin filament binding
actin filament organization
clathrin adaptor activity
clathrin binding
clathrin coat assembly
clathrin light chain binding
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-3,5-bisphosphate binding
phospholipid binding

Displaying **all 7** entries
InterPro
AP180 N-terminal homology (ANTH) domain
ENTH domain
ENTH/VHS
Huntingtin-interacting protein 1, clathrin-binding domain
I/LWEQ domain superfamily
I/LWEQ domain
Sla2 family

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	3092	SGD:S000005187
Xenopus tropicalis	9026	Xenbase:XB-GENE-491211
Mus musculus	29816		MOUSE44381
Rattus norvegicus	81917		RATNO06212
Canis lupus familiaris	486251		CANLF10263
Bos taurus	508291		BOVIN09414
Danio rerio	562138		DANRE36360
Macaca mulatta	707396		MACMU03247
Ornithorhynchus anatinus	100075420		ORNAN16943
Sus scrofa	100154116		PIGXX06742

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements