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kinetochore localized astrin (SPAG5) binding protein

Summary

Gene Symbol

KNSTRN

Organism

Homo sapiens (human)

External Links

NCBI Gene

90417

PubChem

90417

Alliance of Genome Resources

HGNC:30767

Annotation

Keyword

Alternative splicing
Centromere
Chromosome
Coiled coil
Cytoskeleton
Disease variant
Kinetochore
Microtubule
Mitosis
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y448	Kinetochore-localized astrin-binding protein Kinetochore-localized astrin/SPAG5-binding protein TRAF4-associated factor 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IMP	26242911
mitotic sister chromatid segregation	IBA IMP	21402792
cell migration	IMP	26242911
spindle organization	IBA IMP	21402792
cell division	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

spindle organization

cell cycle process [inference]

spindle organization

chromosome segregation

nuclear chromosome segregation [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

mitotic cell cycle process [inference]

mitotic sister chromatid segregation

cell motility [inference]

cell migration

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

spindle organization

chromosome organization [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

response to epidermal growth factor [inference]

cellular response to epidermal growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to epidermal growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to epidermal growth factor stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of attachment of spindle microtubules to kinetochore

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GO Term	Evidence Code	PMID
centriolar satellite	IBA IDA
microtubule organizing center	IDA	29180244
plasma membrane	IDA
spindle pole	IEA
ruffle	IDA	26242911

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

centriolar satellite

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

spindle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

kinetochore

spindle [inference]

mitotic spindle

supramolecular complex [inference]

kinetochore

microtubule end [inference]

microtubule plus-end

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21402792 22965910 26242911 26496610 29180244 32296183 32814053 33961781 35271311
protein homodimerization activity	IPI	26242911
microtubule plus-end binding	IDA	26242911

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding [inference]

microtubule plus-end binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Small kinetochore-associated protein

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
chromosome segregation
regulation of attachment of spindle microtubules to kinetochore

Displaying 1 entry
InterPro
Small kinetochore-associated protein

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3151	skin squamous cell carcinoma	Alliance of Genome Resources
DOID:8866	actinic keratosis	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	51944		MGI:1289298	MOUSE35968
Rattus norvegicus	311325		RGD:1303240	RATNO27167
Macaca mulatta	702753			MACMU42853
Pan troglodytes	738257	9598_0:003e6c		PANTR09976
Danio rerio	792608		ZFIN:ZDB-GENE-081022-187
Equus caballus	100071423			HORSE17398
Xenopus laevis	100158408		Xenbase:XB-GENE-17334133
Xenopus tropicalis	100380161		Xenbase:XB-GENE-974812
Pongo abelii	100431694	9601_0:003bcb		PONAB09352
Ailuropoda melanoleuca	100484732			AILME18888

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements