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Guidelines

MIRAGE

proline-serine-threonine phosphatase interacting protein 1

Summary

Gene Symbol

PSTPIP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9051

PubChem

9051

Alliance of Genome Resources

HGNC:9580

JoGo

PSTPIP1

TogoVar

PSTPIP1

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Coiled coil
Cytoskeleton
Disease variant
Endocytosis
Inflammatory response
Innate immunity
Phosphoprotein
Proteomics identification
Reference proteome
SH3 domain

Proteins

Displaying **all 3** entries
UniProt	Protein Name
J3KPG6
A0A0S2Z5P3
O43586	CD2-binding protein 1 H-PIP

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
endocytosis	IEA
inflammatory response	IEA
cell adhesion	IEA
signal transduction	TAS	9857189
actin filament polymerization

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization [inference]

actin filament polymerization

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
uropod	IEA
cytoplasm	IBA
cytosol	TAS
cytosol	IDA
cytoskeleton	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

plasma membrane region [inference]

cleavage furrow

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11971877 16318909 17964261 18480402 19807924 21516116 24407287 25040622 25416956 25910212 26871637 32296183 35152348 9422760
identical protein binding	IPI	17964261 35152348
actin filament binding

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

identical protein binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

proline-serine-threonine phosphatase interacting protein

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
actin cytoskeleton organization
actin filament binding
actin filament polymerization
microtubule binding
phospholipid binding
vesicle organization

Displaying **all 5** entries
InterPro
AH/BAR domain superfamily
F-BAR domain
FCH domain
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080519	PAPA syndrome	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025