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leucine rich repeat and sterile alpha motif containing 1

Summary

Gene Symbol

LRSAM1

Organism

Homo sapiens (human)

External Links

NCBI Gene

90678

PubChem

90678

Alliance of Genome Resources

HGNC:25135

Annotation

Keyword

Alternative splicing
Autophagy
Charcot-Marie-Tooth disease
Coiled coil
Cytoplasm
Disease variant
Leucine-rich repeat
Neurodegeneration
Phosphoprotein
Protein transport
Reference proteome
Repeat
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6UWE0	Leucine-rich repeat and sterile alpha motif-containing protein 1 RING-type E3 ubiquitin transferase LRSAM1 Tsg101-associated ligase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein polyubiquitination	IDA	18077552
autophagy	IEA
protein catabolic process	IMP	18077552
negative regulation of endocytosis	IMP	15256501
viral budding	IMP	15256501

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

cellular catabolic process [inference]

autophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

ubiquitin-dependent endocytosis

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

process utilizing autophagic mechanism [inference]

autophagy

viral process [inference]

viral budding

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

ubiquitin-dependent endocytosis

organic substance transport [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

nitrogen compound transport [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of xenophagy

positive regulation of response to external stimulus [inference]

positive regulation of xenophagy

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

negative regulation of transport [inference]

negative regulation of endocytosis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of xenophagy [inference]

positive regulation of xenophagy

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of xenophagy

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of xenophagy

positive regulation of response to external stimulus [inference]

positive regulation of xenophagy

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of xenophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of vacuole organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	15256501 18077552
cytosol	IDA
membrane	IDA	15256501

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity	IDA	15256501 18077552
protein binding	IPI	15256501 16189514 16713569 18077552 19549727 19690564 21044950 23245322 25260751 25416956 25484098 27615052 32296183 32814053 33961781
zinc ion binding	IEA
metal ion binding
ubiquitin protein ligase activity	IDA	23245322

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

e3 ubiquitin-protein ligase LRSAM1

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
metal ion binding

Displaying **all 7** entries
InterPro
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat
Sterile alpha motif domain
Sterile alpha motif/pointed domain superfamily
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110169	Charcot-Marie-Tooth disease axonal type 2P	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	90678	Xenbase:XB-GENE-994894
Mus musculus	227738		MOUSE34500
Rattus norvegicus	311866		RATNO27645
Pan troglodytes	464747		PANTR44868
Canis lupus familiaris	491329		CANLF19430
Bos taurus	507008		BOVIN03172
Danio rerio	562066		DANRE36865
Macaca mulatta	700704		MACMU11687
Ciona intestinalis	778885		CIOIN11583
Monodelphis domestica	100011228		MONDO07137

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Annotation

OrthoDB (Group)

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Acknowledgements