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claudin 6

Summary

Gene Symbol

CLDN6

Organism

Homo sapiens (human)

External Links

NCBI Gene

9074

PubChem

9074

Alliance of Genome Resources

HGNC:2048

Annotation

Keyword

Cell membrane
Host cell receptor for virus entry
Host-virus interaction
Phosphoprotein
Reference proteome
Tight junction
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P56747	Skullin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cell adhesion	IBA
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS
viral entry into host cell	IEA
bicellular tight junction assembly	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

tight junction organization [inference]

tight junction assembly [inference]

bicellular tight junction assembly

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA	20375010
plasma membrane	IBA
bicellular tight junction	ISS
bicellular tight junction	IBA
apicolateral plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apicolateral plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

bicellular tight junction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
virus receptor activity	IMP	20375010
structural molecule activity	IEA
protein binding	IPI	20375010 32296183 36935496
identical protein binding	ISS

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

identical protein binding

exogenous protein binding [inference]

virus receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Claudin

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
bicellular tight junction assembly
structural molecule activity

Displaying **all 4** entries
InterPro
Claudin, conserved site
Claudin-6
Claudin
PMP-22/EMP/MP20/Claudin

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9074	Xenbase:XB-GENE-959181
Xenopus tropicalis	9080	Xenbase:XB-GENE-959181
Mus musculus	54419		MOUSE19832
Rattus norvegicus	287098		RATNO01131
Pan troglodytes	467882		PANTR22517
Canis lupus familiaris	490048		CANLF16648
Bos taurus	511318		BOVIN20129
Macaca mulatta	699854		MACMU26676
Equus caballus	100065839		HORSE06718
Sus scrofa	100302020		PIGXX21068