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Guidelines

MIRAGE

ubiquitin specific peptidase 10

Summary

Gene Symbol

USP10

Organism

Homo sapiens (human)

External Links

NCBI Gene

9100

PubChem

9100

Alliance of Genome Resources

HGNC:12608

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Autophagy
Cytoplasm
DNA repair
Endosome
Nucleus
Phosphoprotein
Reference proteome
Thiol protease
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q14694	Deubiquitinating enzyme 10 Ubiquitin thioesterase 10 Ubiquitin-specific-processing protease 10
A0A7G6J4N4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
proteolysis	IEA
autophagy	IEA
DNA damage response	IMP	25861989
cellular response to DNA damage stimulus	IMP	25861989
regulation of autophagy	IDA	21962518

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

catabolic process [inference]

cellular catabolic process [inference]

autophagy

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular catabolic process [inference]

autophagy

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

monoubiquitinated protein deubiquitination

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular catabolic process [inference]

autophagy

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle disassembly [inference]

ribosome disassembly [inference]

rescue of stalled ribosome

cellular component disassembly [inference]

organelle disassembly [inference]

ribosome disassembly [inference]

rescue of stalled ribosome

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of cellular component biogenesis [inference]

regulation of organelle assembly [inference]

regulation of stress granule assembly [inference]

negative regulation of stress granule assembly

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

regulation of organelle assembly [inference]

regulation of stress granule assembly [inference]

negative regulation of stress granule assembly

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of stress granule assembly

regulation of biological quality [inference]

regulation of protein stability

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	20096447 24845384
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
cytoplasm	IDA	20096447

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome [inference]

cytosolic ribosome

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular non-membrane-bounded organelle [inference]

ribosome [inference]

cytosolic ribosome

cytoskeleton [inference]

intermediate filament cytoskeleton

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
p53 binding	IPI	20096447
RNA binding	HDA	22658674 22681889
cysteine-type endopeptidase activity	IMP	21962518
cysteine-type deubiquitinase activity	TAS
cysteine-type deubiquitinase activity	IDA	20096447 21962518 31981475 34348161 34469731

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular function regulator activity [inference]

molecular function inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin carboxyl-terminal hydrolase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
hydrolase activity
regulation of autophagy

Displaying **all 4** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9100	Xenbase:XB-GENE-966184
Mus musculus	22224	Xenbase:XB-GENE-966184	MOUSE58770
Rattus norvegicus	307905		RATNO14498
Pan troglodytes	454287		PANTR12993
Canis lupus familiaris	479625		CANLF15893
Danio rerio	564632		DANRE39621
Xenopus tropicalis	856895	Xenbase:XB-GENE-966184
Monodelphis domestica	100023556		MONDO08920
Ornithorhynchus anatinus	100078827		ORNAN02409
Taeniopygia guttata	100231833		TAEGU03131

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Last updated: April 7, 2025