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exonuclease 1

Summary

Gene Symbol

EXO1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9156

PubChem

9156

Alliance of Genome Resources

HGNC:3511

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
DNA excision
DNA-binding
Direct protein sequencing
Endonuclease
Excision nuclease
Exonuclease
Immunity
Magnesium
Meiosis
Metal-binding
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UQ84	Exonuclease I
A8K5H6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
DNA strand resection involved in replication fork processing	IMP	26240375
humoral immune response mediated by circulating immunoglobulin	IEA
DNA repair	TAS	10364235
isotype switching	IEA
t-circle formation	TAS	27918544

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic diversification of immune receptors via somatic mutation [inference]

somatic hypermutation of immunoglobulin genes

somatic diversification of immunoglobulins [inference]

somatic diversification of immunoglobulins involved in immune response [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic hypermutation of immunoglobulin genes

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

humoral immune response [inference]

humoral immune response mediated by circulating immunoglobulin

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

cell cycle [inference]

meiotic cell cycle

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

mismatch repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

reproductive process [inference]

meiotic cell cycle

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

mismatch repair

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

humoral immune response [inference]

humoral immune response mediated by circulating immunoglobulin

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

mismatch repair

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA
nucleoplasm	IDA TAS
nuclear body	IDA
nucleus	IBA IDA	11429708 14676842

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

nuclear body

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10856833 11427529 11429708 12414623 14676842 15225546 15886194 21052091 2414623 26807646 34552057 9788596
5'-3' DNA exonuclease activity	IBA IDA	10608837
double-stranded DNA 5'-3' exodeoxyribonuclease activity	IDA	10608837 11842105
flap endonuclease activity	IDA	10608837 11842105
DNA binding	IDA	11842105

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

exonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity [inference]

double-stranded DNA 5'-3' exodeoxyribonuclease activity

5'-3' DNA exonuclease activity

5'-3' exonuclease activity

5'-3' DNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity [inference]

double-stranded DNA 5'-3' exodeoxyribonuclease activity

5'-3' DNA exonuclease activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity [inference]

double-stranded DNA 5'-3' exodeoxyribonuclease activity

5'-3' DNA exonuclease activity

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity [inference]

double-stranded DNA 5'-3' exodeoxyribonuclease activity

5'-3' DNA exonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Exonuclease I

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying **all 10** entries
Gene Ontology
5'-3' DNA exonuclease activity
5'-flap endonuclease activity
DNA double-strand break processing
DNA recombination
DNA repair
catalytic activity
hydrolase activity, acting on ester bonds
hydrolase activity
metal ion binding
nuclease activity

Displaying **all 9** entries
InterPro
5'-3' exonuclease, C-terminal domain superfamily
Exonuclease 1-like, PIN-like domain
Exonuclease-1, H3TH domain
Helix-hairpin-helix motif, class 2
PIN-like domain superfamily
XPG conserved site
XPG, N-terminal
XPG-I domain
XPG/Rad2 endonuclease

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5426	primary ovarian insufficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	26909		MGI:1349427	MOUSE27152
Drosophila melanogaster	35119		FB:FBgn0015553
Caenorhabditis elegans	176765		WB:WBGene00009731
Rattus norvegicus	305000		RGD:1309465	RATNO06491
Xenopus laevis	399140		Xenbase:XB-GENE-982081
Danio rerio	406778		ZFIN:ZDB-GENE-040426-2828
Pan troglodytes	457856	9598_0:00079d		PANTR24037
Bos taurus	506390			BOVIN08165
Macaca mulatta	706902			MACMU21390
Saccharomyces cerevisiae S288C	851856		SGD:S000002671

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements