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exonuclease 1

Summary

Gene Symbol

EXO1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9156

PubChem

9156

Alliance of Genome Resources

HGNC:3511

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
DNA excision
DNA-binding
Direct protein sequencing
Endonuclease
Excision nuclease
Exonuclease
Immunity
Magnesium
Meiosis
Metal-binding
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UQ84	Exonuclease I
A8K5H6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
humoral immune response mediated by circulating immunoglobulin	IEA
DNA repair	TAS	10364235
mismatch repair	ISS	9685493
mismatch repair	TAS
mismatch repair	IDA	14636568

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic diversification of immune receptors via somatic mutation [inference]

somatic hypermutation of immunoglobulin genes

somatic diversification of immunoglobulins [inference]

somatic diversification of immunoglobulins involved in immune response [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic hypermutation of immunoglobulin genes

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

humoral immune response [inference]

humoral immune response mediated by circulating immunoglobulin

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

cell cycle [inference]

meiotic cell cycle

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

mismatch repair

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

DNA strand resection involved in replication fork processing

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

mismatch repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

reproductive process [inference]

meiotic cell cycle

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

mismatch repair

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

humoral immune response [inference]

humoral immune response mediated by circulating immunoglobulin

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

mismatch repair

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	11429708 14676842
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

nuclear body

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
DNA binding	IDA	11842105
chromatin binding	IEA
RNA-DNA hybrid ribonuclease activity	TAS	10364235
exonuclease activity	TAS	9788596
protein binding	IPI	10856833 11427529 11429708 12414623 14676842 15225546 15886194 21052091 2414623 26807646 34552057 9788596

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

exonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity [inference]

double-stranded DNA 5'-3' exodeoxyribonuclease activity

5'-3' DNA exonuclease activity

5'-3' exonuclease activity

5'-3' DNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity [inference]

double-stranded DNA 5'-3' exodeoxyribonuclease activity

5'-3' DNA exonuclease activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity [inference]

double-stranded DNA 5'-3' exodeoxyribonuclease activity

5'-3' DNA exonuclease activity

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity [inference]

double-stranded DNA 5'-3' exodeoxyribonuclease activity

5'-3' DNA exonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

exonuclease

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
5'-3' DNA exonuclease activity
5'-flap endonuclease activity
DNA double-strand break processing
DNA recombination
DNA repair
catalytic activity
hydrolase activity, acting on ester bonds
hydrolase activity
metal ion binding
nuclease activity

Displaying **all 9** entries
InterPro
5'-3' exonuclease, C-terminal domain superfamily
Exonuclease 1-like, PIN-like domain
Exonuclease-1, H3TH domain
Helix-hairpin-helix motif, class 2
PIN-like domain superfamily
XPG conserved site
XPG, N-terminal
XPG-I domain
XPG/Rad2 endonuclease

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9156	Xenbase:XB-GENE-982078
Mus musculus	26909		MOUSE27152
Rattus norvegicus	305000		RATNO06491
Pan troglodytes	457856		PANTR24037
Bos taurus	506390		BOVIN08165
Macaca mulatta	706902		MACMU21390
Monodelphis domestica	100020408		MONDO15870
Equus caballus	100054824		HORSE29274
Taeniopygia guttata	100231784		TAEGU20203
Oryctolagus cuniculus	100338764		RABIT05598

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