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MIRAGE
5-hydroxytryptamine receptor 3B

Summary
Gene Symbol
  • HTR3B
Organism
Homo sapiens (human)
NCBI Gene
9177
PubChem
9177
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Ligand-gated ion channel
  • Postsynaptic cell membrane
  • Receptor
  • Reference proteome
  • Signal
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
O95264
  • Serotonin receptor 3B
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 8 in total
GO Term Evidence Code PMID
serotonin receptor signaling pathway
chemical synaptic transmission
monoatomic ion transmembrane transport
ion transmembrane transport
regulation of membrane potential
GO Hierarchy
Displaying all 5 entries
GO Term Evidence Code PMID
excitatory extracellular ligand-gated monoatomic ion channel activity
serotonin-gated monoatomic cation channel activity
serotonin-gated monoatomic cation channel activity
serotonin-gated monoatomic cation channel activity
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
acetylcholine receptor subunit alpha
Functional Category
  • E: Amino acid transport and metabolism
  • T: Signal transduction mechanisms
  • X: Mobilome: prophages, transposons
Displaying all 4 entries
Gene Ontology
extracellular ligand-gated monoatomic ion channel activity
ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
Displaying all 9 entries
InterPro
5-hydroxytryptamine 3 receptor, A subunit
5-hydroxytryptamine 3 receptor
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel
Disease
Disease Ontology
Displaying all 2 entries
DO ID Disease Name Source
DOID:1574 alcohol use disorder
DOID:1596 depressive disorder
Ortholog
Displaying entries 1 - 10 of 49 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
9177 Xenbase:XB-GENE-17334938
57014 ZFIN:ZDB-GENE-071012-4 MOUSE60567
58963 ZFIN:ZDB-GENE-071012-4 RATNO40393
466788 PANTR04370
541055 BOVIN06483
611236 CANLF15272
694830 MACMU11431
100008789 RABIT00600
100406499 CALJA05298
100446989 PONAB04073
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025