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solute carrier family 24 member 1

Summary

Gene Symbol

SLC24A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9187

PubChem

9187

Alliance of Genome Resources

HGNC:10975

Annotation

Keyword

Alternative splicing
Antiport
Calcium transport
Cell membrane
Congenital stationary night blindness
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Sensory transduction
Signal
Symport
Transmembrane helix
Vision

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B4DUG1	Na(+)/K(+)/Ca(2+)-exchange protein 1 Retinal rod Na-Ca+K exchanger Solute carrier family 24 member 1
B4E1W0	Na(+)/K(+)/Ca(2+)-exchange protein 1 Retinal rod Na-Ca+K exchanger Solute carrier family 24 member 1
F5H127	Na(+)/K(+)/Ca(2+)-exchange protein 1 Retinal rod Na-Ca+K exchanger Solute carrier family 24 member 1
O60721	Na(+)/K(+)/Ca(2+)-exchange protein 1 Retinal rod Na-Ca+K exchanger Solute carrier family 24 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
ion transport	TAS
monoatomic ion transport	TAS
calcium ion transport	NAS	7539424
intracellular calcium ion homeostasis	IDA	26631410
intracellular calcium ion homeostasis	IBA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to light intensity

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	RCA	26631410
plasma membrane	TAS
plasma membrane	IDA	26631410
plasma membrane	IBA
cell surface	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
calcium channel activity	IBA
protein binding	IPI	17474147
calcium, potassium:sodium antiporter activity	ISS	10662833
calcium, potassium:sodium antiporter activity	NAS	9478004
calcium, potassium:sodium antiporter activity	TAS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium/potassium/calcium exchanger

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium channel activity
calcium ion transport
calcium, potassium
intracellular calcium ion homeostasis

Displaying **all 3** entries
InterPro
NCX, central ion-binding domain superfamily
Sodium/calcium exchanger membrane region
Sodium/potassium/calcium exchanger

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110868	congenital stationary night blindness 1D	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 41 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9187	Xenbase:XB-GENE-991430
Drosophila melanogaster	25769	FB:FBgn0028704
Xenopus tropicalis	45248	Xenbase:XB-GENE-991430
Rattus norvegicus	56814	Xenbase:XB-GENE-991430	RATNO40109
Drosophila melanogaster	76376	FB:FBgn0028704
Drosophila melanogaster	84550	FB:FBgn0028704
Xenopus tropicalis	172834	Xenbase:XB-GENE-991430
Mus musculus	214111	Xenbase:XB-GENE-991430	MOUSE63461
Bos taurus	282474		BOVIN00482
Pan troglodytes	453521		PANTR10599

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Acknowledgements