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cytokine receptor like factor 1

Summary

Gene Symbol

CRLF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9244

KEGG Gene ID

PubChem

9244

Alliance of Genome Resources

HGNC:2364

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O75462	Cytokine-like factor 1 ZcytoR5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
ureteric bud development	IEA
positive regulation of cell population proliferation	IDA
positive regulation of cell population proliferation	IBA
protein secretion	IDA
cytokine-mediated signaling pathway	IDA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

export from cell [inference]

secretion by cell [inference]

protein secretion

developmental process [inference]

anatomical structure development [inference]

animal gross anatomical part developmental process [inference]

tissue development [inference]

epithelium development [inference]

kidney epithelium development [inference]

mesonephric epithelium development [inference]

mesonephric tubule development [inference]

ureteric bud development

tube development [inference]

mesonephric tubule development [inference]

ureteric bud development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein secretion

protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

protein transport [inference]

protein secretion

secretion [inference]

secretion by cell [inference]

protein secretion

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of motor neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IDA
extracellular region	IEA
obsolete extracellular space
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

extracellular protein-containing complex [inference]

CRLF-CLCF1 complex

cellular anatomical structure [inference]

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytokine receptor activity	IBA
cytokine activity	IDA
ciliary neurotrophic factor receptor binding	IDA
protein binding	IPI
cytokine binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

ciliary neurotrophic factor receptor binding

cytokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

immune receptor activity [inference]

cytokine receptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular carrier activity [inference]

protein carrier activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080329	cold-induced sweating syndrome 1	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	12931	MGI:1340030

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Last updated: April 6, 2026

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