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cytokine receptor like factor 1

Summary

Gene Symbol

CRLF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9244

PubChem

9244

Alliance of Genome Resources

HGNC:2364

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O75462	Cytokine-like factor 1 ZcytoR5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
ureteric bud development	IEA
positive regulation of cell population proliferation	IDA	10966616
positive regulation of cell population proliferation	IBA
cytokine-mediated signaling pathway	IBA
negative regulation of neuron apoptotic process	IDA	10966616

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

kidney epithelium development [inference]

mesonephric epithelium development [inference]

mesonephric tubule development [inference]

ureteric bud development

tube development [inference]

mesonephric tubule development [inference]

ureteric bud development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of motor neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	TAS	9686600
cytosol	TAS
external side of plasma membrane	IBA
receptor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytokine receptor activity	IBA
cytokine activity	IDA	10966616
ciliary neurotrophic factor receptor binding	IDA	10966616
protein binding	IPI	10966616 19933857 26858303
cytokine binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

ciliary neurotrophic factor receptor binding

receptor ligand activity [inference]

cytokine activity

cytokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

immune receptor activity [inference]

cytokine receptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytokine receptor-like factor 1

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Growth hormone/erythropoietin receptor, ligand binding
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080329	cold-induced sweating syndrome 1	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9244	Xenbase:XB-GENE-922456
Mus musculus	12931	Xenbase:XB-GENE-922456	MOUSE60278
Rattus norvegicus	290655		RATNO11058
Danio rerio	436923		DANRE29165
Macaca mulatta	720247		MACMU20216
Pan troglodytes	735722		PANTR17657
Ornithorhynchus anatinus	100077940		ORNAN29071
Equus caballus	100146959		HORSE19914
Taeniopygia guttata	100220468		TAEGU16202
Callithrix jacchus	100385322		CALJA22633

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements