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Guidelines

MIRAGE

aminoacyl tRNA synthetase complex interacting multifunctional protein 1

Summary

Gene Symbol

AIMP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9255

PubChem

9255

Alliance of Genome Resources

HGNC:10648

JoGo

AIMP1

TogoVar

AIMP1

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Angiogenesis
Apoptosis
Coiled coil
Cytokine
Cytoplasm
Direct protein sequencing
Endoplasmic reticulum
Golgi apparatus
Inflammatory response
Isopeptide bond
Leukodystrophy
Nucleus
Phosphoprotein
Protein biosynthesis
Proteomics identification
Reference proteome
Secreted
Ubl conjugation
tRNA-binding

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DNK3
Q12904	Multisynthase complex auxiliary component p43

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
angiogenesis	IEA
negative regulation of endothelial cell proliferation	IDA	11741979
translation	IEA
apoptotic process	IEA
inflammatory response	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

primary metabolic process [inference]

protein metabolic process [inference]

translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cell motility [inference]

cell migration [inference]

leukocyte migration

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of peptide hormone secretion [inference]

regulation of glucagon secretion [inference]

positive regulation of glucagon secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

signaling [inference]

cell-cell signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of peptide hormone secretion [inference]

regulation of glucagon secretion [inference]

positive regulation of glucagon secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of peptide hormone secretion [inference]

regulation of glucagon secretion [inference]

positive regulation of glucagon secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of peptide hormone secretion [inference]

regulation of glucagon secretion [inference]

positive regulation of glucagon secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of peptide hormone secretion [inference]

regulation of glucagon secretion [inference]

positive regulation of glucagon secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of peptide hormone secretion [inference]

regulation of glucagon secretion [inference]

positive regulation of glucagon secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

regulation of peptide hormone secretion [inference]

regulation of glucagon secretion [inference]

positive regulation of glucagon secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of glucagon secretion

Displaying entries **1 - 5** of 9 in total

1

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GO Term	Evidence Code	PMID
extracellular space	ISS
nucleus	IEA
endoplasmic reticulum	IEA
Golgi apparatus	IEA
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

aminoacyl-tRNA synthetase multienzyme complex

catalytic complex [inference]

aminoacyl-tRNA synthetase multienzyme complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
tRNA binding	IDA	11306575
cytokine activity	ISS	11306575
protein binding	IPI	11741979 22190034 24312579 25416956 28514442 32296183 33961781
protein homodimerization activity	IDA	11306575
GTPase binding	IPI	24337748

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

cytokine activity

enzyme binding [inference]

GTPase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

tRNA binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tRNA synthetase

Functional Category

J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
tRNA aminoacylation for protein translation
tyrosine-tRNA ligase activity

Displaying **all 2** entries
InterPro
Nucleic acid-binding, OB-fold
tRNA-binding domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060790	hypomyelinating leukodystrophy 3	Alliance of Genome Resources

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Last updated: December 8, 2025