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glucose-6-phosphatase catalytic subunit 3

Summary

Gene Symbol

G6PC3

Aliases

UGRP

Organism

Homo sapiens (human)

External Links

NCBI Gene

92579

HGNC

24861

KEGG Gene ID

hsa:92579

PubChem

92579

Alliance of Genome Resources

HGNC:24861

Annotation

Keyword

Disease variant
Endoplasmic reticulum
Gluconeogenesis
Hydrolase
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8Q3SIG5
Q9BUM1	Glucose-6-phosphatase beta Ubiquitous glucose-6-phosphatase catalytic subunit-related protein
K7EJC5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glucose 6-phosphate metabolic process	IBA
glucose-6-phosphate transport	IEA
gluconeogenesis	IBA IEA TAS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

carbohydrate derivative metabolic process [inference]

glucose 6-phosphate metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

organophosphate ester transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

carbohydrate derivative transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	TAS
membrane	HDA IBA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
glucose-6-phosphatase activity	EXP IBA IMP TAS	14718531 25492228

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

sugar-terminal-phosphatase activity [inference]

glucose-6-phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01084

Name

glucose-6-phosphatase [EC:3.1.3.9]

References

19700406

Rhea

H₂O + D-glucose 6-phosphate

D-glucose + phosphate

Enzyme

PMID

H₂O + α-D-glucose 6-phosphate

α-D-glucose + phosphate

Enzyme

Disease

Disease Ontology

Displaying entries **1 - 10** of 72 in total

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET
DOID:0050590	severe congenital neutropenia	DisGeNET DisGeNET DisGeNET DisGeNET
DOID:0050632	oculocutaneous albinism	DisGeNET
DOID:0050908	myelodysplastic syndrome	DisGeNET
DOID:0060180	colitis	DisGeNET
DOID:0060189	ileitis	DisGeNET
DOID:0060190	ileocolitis	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0110106	atrial heart septal defect 1	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 50 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000010	Recurrent urinary tract infections
HP:0000023	Inguinal hernia
HP:0000028	Cryptorchidism
HP:0000126	Hydronephrosis
HP:0000155	Oral ulcer
HP:0000175	Cleft palate
HP:0000218	High palate
HP:0000252	Microcephaly
HP:0000365	Hearing impairment

Displaying 1 entry
Disease ID	Disease Name
OMIM:612541	autosomal recessive severe congenital neutropenia due to G6PC3 deficiency

PubChem Disease

MedGen Diseases

Autosomal recessive severe congenital neutropenia due to G6PC3 deficiency

OMIM Phenotypes

NEUTROPENIA, SEVERE CONGENITAL, 4, AUTOSOMAL RECESSIVE; SCN4

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **31 - 40** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Felis catus	101097770		FELCA30949
Panthera leo	122205957		PANLE04363
Tursiops truncatus	101327107		TURTR13454
Balaenoptera musculus	118886111		BALMU10672
Loxodonta africana	100657260		LOXAF10224
Sus scrofa	100512070		PIGXX02182
Bos taurus	369023		BOVIN13473
Capra hircus	102179979		CAPHI11011
Dipodomys ordii	105997519		DIPOR21858
Cricetulus griseus	100753219		CRIGR12827

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024