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adhesion G protein-coupled receptor G1

Summary

Gene Symbol

ADGRG1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9289

PubChem

9289

Alliance of Genome Resources

HGNC:4512

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Developmental protein
Differentiation
Direct protein sequencing
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Heparin-binding
Neurogenesis
Reference proteome
Secreted
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 6** entries
UniProt	Protein Name
A0A024R6U7	G-protein coupled receptor 56
B3KQN7	G-protein coupled receptor 56
Q9Y653	G-protein coupled receptor 56 Protein TM7XN1
B4DM06
B3KQV4	G-protein coupled receptor 56
A0A0S2Z517	G-protein coupled receptor 56

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
angiogenesis	IDA	21724588
cell adhesion	IDA	27068534
cell surface receptor signaling pathway	IEA
G protein-coupled receptor signaling pathway	TAS	10049584 15004227
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell population proliferation [inference]

neural precursor cell proliferation

cellular developmental process [inference]

cell differentiation

cell motility [inference]

cell migration

glial cell migration [inference]

telencephalon glial cell migration [inference]

cerebral cortex radial glia-guided migration

forebrain cell migration [inference]

telencephalon cell migration [inference]

cerebral cortex cell migration [inference]

cerebral cortex radially oriented cell migration [inference]

cerebral cortex radial glia-guided migration

telencephalon glial cell migration [inference]

cerebral cortex radial glia-guided migration

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

seminiferous tubule development

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

cerebral cortex regionalization

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

seminiferous tubule development

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

tube development [inference]

seminiferous tubule development

animal organ development [inference]

brain development

reproductive structure development [inference]

seminiferous tubule development

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

signaling [inference]

cell-cell signaling

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of cell adhesion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to vascular endothelial growth factor stimulus [inference]

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation

negative regulation of cell population proliferation

regulation of neural precursor cell proliferation [inference]

positive regulation of neural precursor cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of cell adhesion

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region
plasma membrane	IBA
membrane	TAS	15004227
membrane raft	IEA
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

plasma membrane

membrane microdomain [inference]

membrane raft

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot [inference]

glial limiting end-foot

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor activity	ISS
G protein-coupled receptor activity	IBA
protein binding	IPI	28258187
collagen binding	ISS
heparin binding	IDA	27068534

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Adhesion G-protein coupled receptor G1

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cell differentiation
cell surface receptor signaling pathway
heparin binding
nervous system development

Displaying **all 6** entries
InterPro
GAIN domain superfamily
GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM
GPS motif
PTX/LNS-Like (PLL) domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080922	bilateral frontoparietal polymicrogyria	Alliance of Genome Resources
DOID:0080924	bilateral perisylvian polymicrogyria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9289	Xenbase:XB-GENE-6041837
Mus musculus	14766	Xenbase:XB-GENE-6041837	MOUSE59577
Rattus norvegicus	260326		RATNO15173
Bos taurus	509703		BOVIN10519
Macaca mulatta	613233		MACMU27308
Pan troglodytes	737751		PANTR12464
Monodelphis domestica	100025706		MONDO07893
Equus caballus	100062615		HORSE30727
Ornithorhynchus anatinus	100077213		ORNAN03573
Pongo abelii	100189892		PONAB10950

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements