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methionyl-tRNA synthetase 2, mitochondrial

Summary

Gene Symbol

MARS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

92935

PubChem

92935

Alliance of Genome Resources

HGNC:25133

Annotation

Keyword

ATP-binding
Aminoacyl-tRNA synthetase
Deafness
Disease variant
Mitochondrion
Neurodegeneration
Primary mitochondrial disease
Protein biosynthesis
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96GW9	Methionyl-tRNA synthetase 2 Mitochondrial methionyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
tRNA aminoacylation for protein translation	TAS
methionyl-tRNA aminoacylation	IBA IDA	15274629

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	HTP IBA	34800366
mitochondrial matrix	IDA TAS	15274629

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
methionine-tRNA ligase activity	IBA IDA TAS	15274629
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

methionine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA ligase activity [inference]

methionine-tRNA ligase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

methionine--trna ligase

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
V: Defense mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
ligase activity
methionine-tRNA ligase activity
methionyl-tRNA aminoacylation
nucleotide binding
tRNA aminoacylation for protein translation

Displaying **all 9** entries
InterPro
Aminoacyl-tRNA synthetase, class I, conserved site
Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Methionine-tRNA ligase, type 1
Methioninyl-tRNA synthetase core domain
Methionyl-tRNA synthetase, Zn-domain
Methionyl-tRNA synthetase, anticodon-binding domain
Methionyl-tRNA synthetase
Methionyl/Leucyl tRNA synthetase
Rossmann-like alpha/beta/alpha sandwich fold

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050942	spastic ataxia 3	Alliance of Genome Resources
DOID:0111468	combined oxidative phosphorylation deficiency 25	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:700	mitochondrial metabolism disease	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Jaculus jaculus	101595512			JACJA04910
Mustela putorius furo	101685169			MUSPF04942
Ficedula albicollis	101812633			FICAL11638
Chrysemys picta bellii	101942879			CHRPI24709
Ictidomys tridecemlineatus	101970542			ICTTR03364
Chinchilla lanigera	102024415			CHILA00424
Macaca fascicularis	102116639			MACFA05700
Capra hircus	102182835			CAPHI20572
Haplochromis burtoni	102309655			HAPBU00951
Latimeria chalumnae	102362044			LATCH16361

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Last updated: December 9, 2024