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sphingosine-1-phosphate receptor 2

Summary

Gene Symbol

S1PR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9294

PubChem

9294

Alliance of Genome Resources

HGNC:3169

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
G-protein coupled receptor
Glycoprotein
Non-syndromic deafness
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O95136	Endothelial differentiation G-protein coupled receptor 5 Sphingosine 1-phosphate receptor Edg-5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
regulation of postsynapse assembly	IEA
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

plasma membrane bounded cell projection organization [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

negative regulation of biological process [inference]

negative regulation of excitatory postsynaptic potential

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

Displaying **all 5** entries
GO Term	Evidence Code	PMID
postsynapse	IEA
presynapse	IEA
plasma membrane	IBA IDA TAS	24851274 29453251
cytoplasm	IBA
glutamatergic synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	24453941 24851274
integrin binding	IPI	24851274
sphingosine-1-phosphate receptor activity	IBA IDA IMP	23106337 29453251
G protein-coupled receptor binding	IPI	24851274
G protein-coupled peptide receptor activity	IPI	29453251

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cell adhesion molecule binding [inference]

integrin binding

lipid binding

protein-containing complex binding [inference]

integrin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity

bioactive lipid receptor activity [inference]

sphingosine-1-phosphate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sphingosine 1-phosphate receptor

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
sphingosine-1-phosphate receptor activity

Displaying **all 4** entries
InterPro
EDG-5 sphingosine 1-phosphate receptor
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Sphingosine 1-phosphate receptor

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060060	non-Hodgkin lymphoma	Alliance of Genome Resources
DOID:0110519	autosomal recessive nonsyndromic deafness 68	Alliance of Genome Resources
DOID:305	carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14739		MGI:99569	MOUSE62605
Rattus norvegicus	29415		RGD:68334	RATNO39844
Danio rerio	170457		ZFIN:ZDB-GENE-020123-2	DANRE32375
Bos taurus	540305			BOVIN32580
Macaca mulatta	712143			MACMU20150
Monodelphis domestica	100012444			MONDO20424
Equus caballus	100058299			HORSE38637
Ornithorhynchus anatinus	100080873			ORNAN30222
Callithrix jacchus	100392405			CALJA22753
Pongo abelii	100435839	9601_0:004831

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Last updated: December 9, 2024