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cerberus 1, DAN family BMP antagonist

Summary

Gene Symbol

CER1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9350

PubChem

9350

Alliance of Genome Resources

HGNC:1862

JoGo

CER1

TogoVar

CER1

Annotation

Keyword

Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O95813	Cerberus-related protein DAN domain family member 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
ureteric bud development	ISS
growth plate cartilage chondrocyte proliferation	ISS	19113921
gastrulation	ISS	10049596
nervous system development	IMP	9660951
negative regulation of cell population proliferation	ISS	10049596

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

signal transduction involved in regulation of gene expression

cell population proliferation [inference]

growth plate cartilage chondrocyte proliferation

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

cell migration involved in gastrulation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to cadmium ion

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

dorsal/ventral pattern formation [inference]

determination of dorsal identity

axis specification [inference]

anterior/posterior axis specification

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry [inference]

determination of heart left/right asymmetry

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

epithelium development [inference]

kidney epithelium development [inference]

mesonephric epithelium development [inference]

mesonephric tubule development [inference]

ureteric bud development

tube development [inference]

mesonephric tubule development [inference]

ureteric bud development

system development [inference]

nervous system development

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to cadmium ion [inference]

cellular response to cadmium ion

cellular response to metal ion [inference]

cellular response to cadmium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to cadmium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to cadmium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to cadmium ion

localization [inference]

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in extracellular region [inference]

sequestering of BMP in extracellular matrix

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of developmental process [inference]

negative regulation of mesoderm development

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of mesoderm development

regulation of mesoderm development [inference]

negative regulation of mesoderm development

regulation of cellular process [inference]

signal transduction [inference]

signal transduction involved in regulation of gene expression

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	ISS	10049596
extracellular region	TAS
extracellular space	ISS
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytokine activity	IEA
morphogen activity	IDA	9660951
morphogen activity	IBA
BMP binding	IDA	9660951
protein homodimerization activity	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

cytokine binding [inference]

BMP binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cerberus

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
animal organ development
determination of heart left/right asymmetry
negative regulation of activin receptor signaling pathway
regionalization

Displaying **all 4** entries
InterPro
Cerberus
Cystine knot, C-terminal
Cystine-knot cytokine
DAN

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements