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imidazole glycerol phosphate synthase subunit

Summary

Gene Symbol

hisF

Organism

Bacillus subtilis subsp. subtilis str. 168

External Links

NCBI Gene: 936554
PubChem: 936554

Annotation

Keyword

Cytoplasm
Histidine biosynthesis
Lyase
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O34727	IGP synthase cyclase subunit IGP synthase subunit HisF ImGP synthase subunit HisF
A0A6M3ZJL1	IGP synthase cyclase subunit IGP synthase subunit HisF ImGP synthase subunit HisF

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
histidine biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
imidazoleglycerol-phosphate synthase activity
lyase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

imidazoleglycerol-phosphate synthase activity

lyase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Bacteria

Group Name

1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
K: Transcription

Displaying **all 4** entries
Gene Ontology
amino acid biosynthetic process
histidine biosynthetic process
imidazoleglycerol-phosphate synthase activity
lyase activity

Displaying **all 4** entries
InterPro
Aldolase-type TIM barrel
Histidine biosynthesis protein
Histidine biosynthesis, HisF
Ribulose-phosphate binding barrel

Rhea

RHEA:24793

L-glutamine + 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide

H⁺ + L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide

Enzyme

4.3.2.10

PMID

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.2.1

Last updated: April 7, 2025

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