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neurexin 2

Summary

Gene Symbol

NRXN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9379

PubChem

9379

Alliance of Genome Resources

HGNC:8009

Annotation

Keyword

3D-structure
Alternative promoter usage
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cell projection
Disulfide bond
EGF-like domain
Heparan sulfate
Metal-binding
Proteomics identification
Reference proteome
Repeat
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P58401	Neurexin II-beta
Q9P2S2	Neurexin II-alpha Neurexin-2-alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
neuron cell-cell adhesion	TAS	18923512
signal transduction	ISS
signal transduction	NAS	18923512
chemical synaptic transmission	ISS
neurotransmitter secretion	ISS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell adhesion [inference]

cell-cell adhesion [inference]

neuron cell-cell adhesion

signal transduction

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

protein localization to cell junction [inference]

protein localization to synapse [inference]

gephyrin clustering involved in postsynaptic density assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

membrane assembly [inference]

postsynaptic membrane assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

membrane organization [inference]

postsynaptic membrane organization [inference]

postsynaptic membrane assembly

membrane assembly [inference]

postsynaptic membrane assembly

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

behavior [inference]

learning or memory [inference]

learning [inference]

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

mechanosensory behavior [inference]

auditory behavior [inference]

vocal learning

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

protein localization to cell junction [inference]

protein localization to synapse [inference]

gephyrin clustering involved in postsynaptic density assembly

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell [inference]

neurotransmitter secretion

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

protein localization to cell junction [inference]

protein localization to synapse [inference]

gephyrin clustering involved in postsynaptic density assembly

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
protein-containing complex	IEA
presynaptic membrane	IEA
cell projection	IEA
glutamatergic synapse	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	ISS
transmembrane signaling receptor activity	NAS	18923512
calcium channel regulator activity	ISS
metal ion binding	IEA
cell adhesion molecule binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

neuroligin family protein binding

cell adhesion molecule binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

neurexin-1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like domain
Laminin G domain

Ortholog

Displaying entries **1 - 10** of 52 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9369	FB:FBgn0038975
Drosophila melanogaster	9378	FB:FBgn0038975
Xenopus tropicalis	9379	Xenbase:XB-GENE-6039577
Drosophila melanogaster	18189	FB:FBgn0038975
Mus musculus	18190		MOUSE25563
Drosophila melanogaster	18191	FB:FBgn0038975
Drosophila melanogaster	60391	FB:FBgn0038975
Drosophila melanogaster	116508	FB:FBgn0038975
Rattus norvegicus	116595	Xenbase:XB-GENE-6039577	RATNO17759
Pan troglodytes	451297		PANTR03311