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heparan sulfate 6-O-sulfotransferase 1
Summary
- Gene Symbol
-
- HS6ST1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Coiled coil
- Disease variant
- Glycoprotein
- Hypogonadotropic hypogonadism
- Kallmann syndrome
- Reference proteome
- Signal-anchor
- Transferase
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| O60243 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| neuron development | ||
| labyrinthine layer blood vessel development | ||
| lung alveolus development | ||
| heparan sulfate proteoglycan biosynthetic process, enzymatic modification | ||
| angiogenesis |
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| Golgi membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| sulfotransferase activity | ||
| heparan sulfate 6-O-sulfotransferase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- heparan sulfate 6-O-sulfotransferase
- Functional Category
-
- G: Carbohydrate transport and metabolism
- H: Coenzyme transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
| Gene Ontology |
|---|
| heparan sulfate 6-O-sulfotransferase activity |
| heparan sulfate proteoglycan biosynthetic process, enzymatic modification |
| sulfotransferase activity |
| transferase activity |
| InterPro |
|---|
| Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase |
| P-loop containing nucleoside triphosphate hydrolase |
| Sulfotransferase |
GlycoGene Database (GGDB)
- GGDB ID
- gg031
- Gene Symbol
-
- HS6ST1
- Orthologous Gene
| Species | Protein | mRNA |
|---|---|---|
| Drosophila melanogaster | NP_524409 | NM_079685 |
| Rattus norvegicus | XP_237060 | XM_237060 |
| Caenorhabditis elegans | NP_508895 | NM_076494 |
| Mus musculus | NP_056633 | NM_015818 |
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0090075 | hypogonadotropic hypogonadism 15 with or without anosmia |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0008527 | Congenital sensorineural hearing impairment |
| HP:0008724 | Hypoplasia of the ovary |
| HP:0008734 | Decreased testicular size |
| HP:0008736 | Hypoplasia of penis |
| HP:0009804 | Tooth agenesis |
| HP:0010550 | Paraplegia |
| HP:0011961 | Non-obstructive azoospermia |
| HP:0012385 | Camptodactyly |
| HP:0012506 | Small pituitary gland |
| HP:0030680 | Abnormal cardiovascular system morphology |
| Disease ID | Disease Name |
|---|---|
| ORPHA:478 |
|
| ORPHA:432 |
|
| OMIM:614880 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 122228763 | PANLE10922 | |||
| 123779490 | URSAM26846 | |||
| 129031685 | 9600_0:000d0d |
