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Guidelines

MIRAGE

penicillin-binding protein 2C (1F class) required for spore germination

Summary

Gene Symbol

pbpF

Organism

Bacillus subtilis subsp. subtilis str. 168

External Links

NCBI Gene: 939766
KEGG Gene ID: bsu:BSU10110
PubChem: 939766

Annotation

Keyword

Carboxypeptidase
Cell membrane
Cell wall biogenesis/degradation
Glycosyltransferase
Multifunctional enzyme
Peptidoglycan synthesis
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A6M3Z979
P38050	Penicillin-binding protein F

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proteolysis
regulation of cell shape
peptidoglycan biosynthetic process
response to antibiotic
cell wall organization

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

protein metabolic process [inference]

proteolysis

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

protein metabolic process [inference]

proteolysis

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

protein metabolic process [inference]

proteolysis

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall organization or biogenesis [inference]

cell wall organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

external encapsulating structure organization [inference]

cell wall organization

response to stimulus [inference]

response to chemical [inference]

response to antibiotic

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of biological quality [inference]

regulation of cell shape

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
penicillin binding
peptidoglycan glycosyltransferase activity
serine-type D-Ala-D-Ala carboxypeptidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

peptidoglycan glycosyltransferase activity

hydrolase activity [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

binding [inference]

amide binding [inference]

penicillin binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

penicillin binding

heterocyclic compound binding [inference]

penicillin binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

penicillin binding

organic cyclic compound binding [inference]

penicillin binding

sulfur compound binding [inference]

penicillin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Bacteria

Group Name

penicillin-binding protein

Functional Category

K: Transcription
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
carboxypeptidase activity
catalytic activity
hydrolase activity
penicillin binding
peptidoglycan glycosyltransferase activity
proteolysis
response to antibiotic

Displaying **all 5** entries
InterPro
Beta-lactamase/transpeptidase-like
Glycosyl transferase, family 51
Lysozyme-like domain superfamily
Penicillin binding protein transglycosylase domain
Penicillin-binding protein, transpeptidase

KEGG BRITE Database

Orthology

K12555

Name

penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4]

References

8335642

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025