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dedicator of cyto-kinesis 2

Summary

Gene Symbol

Dock2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

94176

PubChem

94176

Alliance of Genome Resources

MGI:2149010

Annotation

Keyword

Acetylation
Cytoplasm
Cytoskeleton
Guanine-nucleotide releasing factor
Membrane
Phosphoprotein
Reference proteome
SH3 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8C3J5	Protein Hch
Q6A0A3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
membrane raft polarization	IMP	12871644
establishment of T cell polarity	IMP	12871644
immunological synapse formation	IMP	12871644
myeloid dendritic cell activation involved in immune response	IMP	21892172
chemotaxis	IMP	11518968

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

T cell selection [inference]

positive T cell selection [inference]

positive thymic T cell selection

negative T cell selection [inference]

negative thymic T cell selection

thymic T cell selection [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell activation involved in immune response

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

lymphocyte activation [inference]

T cell activation

T cell proliferation

alpha-beta T cell proliferation

alpha-beta T cell activation

alpha-beta T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

alpha-beta T cell proliferation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell activation involved in immune response

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

lymphocyte activation [inference]

T cell activation

T cell proliferation

alpha-beta T cell proliferation

alpha-beta T cell activation

alpha-beta T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

alpha-beta T cell proliferation

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of lymphocyte polarity [inference]

establishment of T cell polarity

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

cell recognition [inference]

cell-cell recognition [inference]

immunological synapse formation

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation

alpha-beta T cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

pinocytosis [inference]

macropinocytosis

actin filament-based process [inference]

actin cytoskeleton organization

cell motility [inference]

cell migration

cellular localization [inference]

localization within membrane [inference]

membrane raft localization [inference]

membrane raft distribution [inference]

membrane raft polarization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

actin cytoskeleton organization

membrane organization [inference]

membrane raft organization [inference]

membrane raft distribution [inference]

membrane raft polarization

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell activation involved in immune response

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

lymphocyte activation [inference]

T cell activation

T cell proliferation

alpha-beta T cell proliferation

alpha-beta T cell activation

alpha-beta T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

alpha-beta T cell proliferation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

locomotion [inference]

taxis [inference]

chemotaxis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

pinocytosis [inference]

macropinocytosis

import into cell [inference]

endocytosis [inference]

pinocytosis [inference]

macropinocytosis

cellular localization [inference]

localization within membrane [inference]

membrane raft localization [inference]

membrane raft distribution [inference]

membrane raft polarization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA
cytoskeleton	IEA
plasma membrane	IBA
endomembrane system	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	ISS
guanyl-nucleotide exchange factor activity	ISO
guanyl-nucleotide exchange factor activity	IBA
GTPase activator activity	IMP	12871644
small GTPase binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

T cell receptor binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

protein-containing complex binding [inference]

T cell receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dedicator of cytokinesis protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cell migration
myoblast fusion
small GTPase-mediated signal transduction

Displaying entries **1 - 10** of 11 in total

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InterPro
C2 DOCK-type domain
C2 domain superfamily
DOCKER domain
DOCKER, Lobe A
DOCKER, Lobe B
DOCKER, Lobe C
Dedicator of cytokinesis, C-terminal, lobe A
Dedicator of cytokinesis, C-terminal, lobe C
Dedicator of cytokinesis, N-terminal domain
Dedicator of cytokinesis, N-terminal, subdomain 1

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements