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Guidelines

MIRAGE

dedicator of cyto-kinesis 2

Summary

Gene Symbol

Dock2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

94176

PubChem

94176

Alliance of Genome Resources

MGI:2149010

Annotation

Keyword

Acetylation
Cytoplasm
Cytoskeleton
Guanine-nucleotide releasing factor
Membrane
Phosphoprotein
Reference proteome
SH3 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8C3J5	Protein Hch
Q6A0A3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 19 in total

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GO Term	Evidence Code	PMID
cytoskeleton organization	IDA	11518968
small GTPase mediated signal transduction	IEA
myoblast fusion	IBA
cell migration	IBA
actin cytoskeleton organization	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

T cell selection [inference]

positive T cell selection [inference]

positive thymic T cell selection

negative T cell selection [inference]

negative thymic T cell selection

thymic T cell selection [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell activation involved in immune response

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

lymphocyte activation [inference]

T cell activation

T cell proliferation

alpha-beta T cell proliferation

alpha-beta T cell activation

alpha-beta T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

alpha-beta T cell proliferation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell activation involved in immune response

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

lymphocyte activation [inference]

T cell activation

T cell proliferation

alpha-beta T cell proliferation

alpha-beta T cell activation

alpha-beta T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

alpha-beta T cell proliferation

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of lymphocyte polarity [inference]

establishment of T cell polarity

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

cell recognition [inference]

cell-cell recognition [inference]

immunological synapse formation

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation

alpha-beta T cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

pinocytosis [inference]

macropinocytosis

actin filament-based process [inference]

actin cytoskeleton organization

cell motility [inference]

cell migration

cellular localization [inference]

localization within membrane [inference]

membrane raft localization [inference]

membrane raft distribution [inference]

membrane raft polarization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

actin cytoskeleton organization

membrane organization [inference]

membrane raft organization [inference]

membrane raft distribution [inference]

membrane raft polarization

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell activation involved in immune response

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

leukocyte activation involved in immune response [inference]

myeloid cell activation involved in immune response [inference]

myeloid dendritic cell activation involved in immune response

lymphocyte activation [inference]

T cell activation

T cell proliferation

alpha-beta T cell proliferation

alpha-beta T cell activation

alpha-beta T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

alpha-beta T cell proliferation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

locomotion [inference]

taxis [inference]

chemotaxis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

pinocytosis [inference]

macropinocytosis

import into cell [inference]

endocytosis [inference]

pinocytosis [inference]

macropinocytosis

cellular localization [inference]

localization within membrane [inference]

membrane raft localization [inference]

membrane raft distribution [inference]

membrane raft polarization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA
cytoskeleton	IEA
plasma membrane	IBA
endomembrane system	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	ISS
guanyl-nucleotide exchange factor activity	ISO
guanyl-nucleotide exchange factor activity	IBA
GTPase activator activity	IMP	12871644
small GTPase binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

T cell receptor binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

protein-containing complex binding [inference]

T cell receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dedicator of cytokinesis protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cell migration
myoblast fusion
small GTPase-mediated signal transduction

Displaying entries **1 - 10** of 11 in total

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InterPro
C2 DOCK-type domain
C2 domain superfamily
DOCKER domain
DOCKER, Lobe A
DOCKER, Lobe B
DOCKER, Lobe C
Dedicator of cytokinesis, C-terminal, lobe A
Dedicator of cytokinesis, C-terminal, lobe C
Dedicator of cytokinesis, N-terminal domain
Dedicator of cytokinesis, N-terminal, subdomain 1

Ortholog

Displaying entries **61 - 67** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Sparus aurata	115568886		SPAAU63381
Strigops habroptila	115615504		STRHB13303
Corvus moneduloides	116451298		CORMO04224
Chelonoidis abingdonii	116838461		CHEAB16174
Rhinolophus ferrumequinum	117016732		RHIFE23135
Balaenoptera musculus	118893440		BALMU06882
Panthera leo	122224778		PANLE13260

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Last updated: December 8, 2025