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N-acetylneuraminic acid synthase (sialic acid synthase)

Summary

Gene Symbol

Nans

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

94181

PubChem

94181

Alliance of Genome Resources

MGI:2149820

Annotation

Keyword

Acetylation
Cytoplasm
Phosphoprotein
Reference proteome
Transferase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99J77	N-acetylneuraminate-9-phosphate synthase N-acetylneuraminic acid phosphate synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
carbohydrate biosynthetic process	IEA
N-acetylneuraminate biosynthetic process	IEA ISO	31121216
CMP-N-acetylneuraminate biosynthetic process	IEA
glycosylation	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

amide metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

phosphorus metabolic process [inference]

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate biosynthetic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate biosynthetic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

phosphorus metabolic process [inference]

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IDA	10873658

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying 1 entry
GO Term	Evidence Code	PMID
N-acylneuraminate-9-phosphate synthase activity	IBA IDA	10873658

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

N-acylneuraminate-9-phosphate synthase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

sialic acid synthase

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis

Displaying 1 entry
Gene Ontology
glycosylation

Displaying **all 5** entries
InterPro
Aldolase-type TIM barrel
Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily
Antifreeze-like/N-acetylneuraminic acid synthase C-terminal
N-acetylneuraminic acid synthase, N-terminal
SAF domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080576	spondyloepimetaphyseal dysplasia, Genevieve-type	Alliance of Genome Resources

Ortholog

Displaying entries **111 - 116** of **116** in total

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Species	Gene ID	OrthoDB
Phodopus roborovskii	127224641	109678_0:00226d
Apodemus sylvaticus	127680771	10129_0:00101e
Peromyscus californicus insignis	128097358	564181_0:0040b1
Psammomys obesus	129675273	48139_1:0013a1
Chionomys nivalis	130887937	269649_0:003d83
Peromyscus eremicus	131903616	42410_0:000cc4

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements