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ATP binding cassette subfamily G member 2 (JR blood group)

Summary

Gene Symbol

ABCG2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9429

PubChem

9429

Alliance of Genome Resources

HGNC:74

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Lipid transport
Mitochondrion
Phosphoprotein
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UNQ0	ATP-binding cassette sub-family G member 2 Breast cancer resistance protein CDw338 Mitoxantrone resistance-associated protein Placenta-specific ATP-binding cassette transporter Urate exporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
lipid transport	IEA
organic anion transport	ISS
urate transport	IEA
biotin transport	ISS
sphingolipid biosynthetic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

small molecule metabolic process [inference]

urate metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic cyclic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

transmembrane transport

export across plasma membrane

export from cell [inference]

export across plasma membrane

cellular detoxification

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport across blood-brain barrier

renal system process [inference]

renal tubular secretion [inference]

renal urate salt excretion

excretion [inference]

renal tubular secretion [inference]

renal urate salt excretion

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport across blood-brain barrier

xenobiotic transport [inference]

xenobiotic transport across blood-brain barrier

vitamin transport [inference]

transmembrane transport

export across plasma membrane

transepithelial transport

organic substance transport [inference]

lipid transport

organic anion transport

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

biotin transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

biotin transport

nitrogen compound transport [inference]

amide transport [inference]

biotin transport

sulfur compound transport [inference]

biotin transport

export from cell [inference]

export across plasma membrane

detoxification [inference]

cellular detoxification

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
plasma membrane	TAS
plasma membrane	IDA	18619525 23137377
plasma membrane	IBA
apical plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

mitochondrial membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

membrane microdomain [inference]

membrane raft

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	18056989 19909340 26065921
ATP binding	IEA
organic anion transmembrane transporter activity	ISS
ABC-type xenobiotic transporter activity	IDA	9861027
urate transmembrane transporter activity	IDA	36749388

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

sphingolipid transporter activity

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

biotin transmembrane transporter activity

organic anion transmembrane transporter activity

riboflavin transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

biotin transmembrane transporter activity

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

amide transmembrane transporter activity [inference]

biotin transmembrane transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

vitamin transmembrane transporter activity [inference]

sulfur compound transmembrane transporter activity [inference]

biotin transmembrane transporter activity

salt transmembrane transporter activity [inference]

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-binding cassette

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 5** entries
InterPro
AAA+ ATPase domain
ABC transporter family G domain
ABC transporter-like, ATP-binding domain
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:13189	gout	Alliance of Genome Resources
DOID:3602	toxic encephalopathy	Alliance of Genome Resources
DOID:4450	renal cell carcinoma	Alliance of Genome Resources
DOID:707	B-cell lymphoma	Alliance of Genome Resources
DOID:8552	chronic myeloid leukemia	Alliance of Genome Resources
DOID:9538	multiple myeloma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9429	Xenbase:XB-GENE-991895
Caenorhabditis elegans	9619	WB:WBGene00017179
Mus musculus	26357	Xenbase:XB-GENE-991895	MOUSE49634
Danio rerio	31271	ZFIN:ZDB-GENE-050517-38
Xenopus tropicalis	39836	Xenbase:XB-GENE-991895
Caenorhabditis elegans	64137	WB:WBGene00017179
Rattus norvegicus	312382	Xenbase:XB-GENE-991895	RATNO29675
Sus scrofa	397073		PIGXX34445
Pan troglodytes	471251		PANTR34094
Canis lupus familiaris	478472		CANLF13058