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lipid A disaccharide synthase

Summary

Gene Symbol

lpxB

Organism

Escherichia coli str. K-12 substr. MG1655

External Links

NCBI Gene: 944838
PubChem: 944838

Annotation

Keyword

3D-structure
Glycosyltransferase
Lipid A biosynthesis
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P10441

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
lipid A biosynthetic process	IBA IEA IEP IMP	3531165 381294 6370995

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipooligosaccharide biosynthetic process [inference]

lipid A biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipooligosaccharide biosynthetic process [inference]

lipid A biosynthetic process

lipooligosaccharide metabolic process [inference]

lipid A metabolic process [inference]

lipid A biosynthetic process

lipooligosaccharide biosynthetic process [inference]

lipid A biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipooligosaccharide biosynthetic process [inference]

lipid A biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

lipid A biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

lipid A biosynthetic process

lipid A metabolic process [inference]

lipid A biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	6370995
extrinsic component of cytoplasmic side of plasma membrane	IC	19883124
extrinsic component of plasma membrane	IDA	19883124

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

extrinsic component of membrane [inference]

extrinsic component of plasma membrane

extrinsic component of cytoplasmic side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
glycosyltransferase activity	IEA
lipid-A-disaccharide synthase activity	IDA IEA	3049593 6370995
phospholipid binding	IBA IDA	19883124
protein binding	IPI	15690043 8982270
identical protein binding	IDA	3049593

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

lipid-A-disaccharide synthase activity

hexosyltransferase activity [inference]

lipid-A-disaccharide synthase activity

binding [inference]

protein binding

identical protein binding

lipid binding [inference]

phospholipid binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine

H⁺ + UDP + lipid A disaccharide (E. coli)

Enzyme

2.4.1.182

PMID

a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosamine + a lipid X

H⁺ + a lipid A disaccharide + UDP

Enzyme

2.4.1.182

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007693
Gene Name: tetraacyldisaccharide-1-P synthase

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024