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eukaryotic translation initiation factor 2 alpha kinase 3

Summary

Gene Symbol

EIF2AK3

Organism

Homo sapiens (human)

External Links

NCBI Gene

9451

PubChem

9451

Alliance of Genome Resources

HGNC:3255

JoGo

EIF2AK3

TogoVar

EIF2AK3

Annotation

Keyword

3D-structure
ADP-ribosylation
ATP-binding
Diabetes mellitus
Disease variant
Endoplasmic reticulum
Glycoprotein
Initiation factor
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase
Signal
Stress response
Translation regulation
Transmembrane helix
Tyrosine-protein kinase
Unfolded protein response

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A804HIT4	PRKR-like endoplasmic reticulum kinase Pancreatic eIF2-alpha kinase Protein tyrosine kinase EIF2AK3
Q9NZJ5	PRKR-like endoplasmic reticulum kinase Pancreatic eIF2-alpha kinase Protein tyrosine kinase EIF2AK3
B3KY45	PRKR-like endoplasmic reticulum kinase Pancreatic eIF2-alpha kinase Protein tyrosine kinase EIF2AK3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 41 in total

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GO Term	Evidence Code	PMID
skeletal system development	ISS
ossification	IMP	12086964
angiogenesis	IMP	22915762
chondrocyte development	ISS
chromatin remodeling	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

cellular developmental process [inference]

cell development [inference]

chondrocyte development

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress

ER overload response

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to cold

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to biotic stimulus [inference]

ER overload response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

endocrine pancreas development

cell development [inference]

chondrocyte development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell development [inference]

chondrocyte development

response to stimulus [inference]

response to stress [inference]

response to cold [inference]

cellular response to cold

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress

ER overload response

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to cold

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

response to starvation [inference]

cellular response to starvation [inference]

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

response to starvation [inference]

cellular response to starvation [inference]

response to amino acid starvation [inference]

cellular response to amino acid starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

response to biotic stimulus [inference]

cellular response to biotic stimulus [inference]

ER overload response

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold [inference]

cellular response to cold

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to manganese ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress

ER overload response

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to cold

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to biotic stimulus [inference]

ER overload response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of myelination

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

regulation of myelination [inference]

negative regulation of myelination

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of myelination

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
cytoplasm	ISS
cytoplasm	IBA
endoplasmic reticulum	ISS
endoplasmic reticulum	TAS	12086964

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

organelle membrane contact site [inference]

mitochondria-associated endoplasmic reticulum membrane

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
protein kinase activity	TAS	10026192
protein serine/threonine kinase activity	ISS
3-phosphoinositide-dependent protein kinase activity	IEA
DNA-dependent protein kinase activity	IEA
AMP-activated protein kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

protein tyrosine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

protein tyrosine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

protein tyrosine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

binding [inference]

protein binding

enzyme binding

phosphatase binding [inference]

protein phosphatase binding

heat shock protein binding [inference]

Hsp90 protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

translation regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

eukaryotic translation initiation factor 2 alpha kinase 3

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
cellular response to chemical stimulus
eukaryotic translation initiation factor 2alpha kinase activity
kinase activity
nucleotide binding
phosphorylation
response to endoplasmic reticulum stress
response to unfolded protein

Displaying **all 6** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Quinoprotein alcohol dehydrogenase-like superfamily
Serine/threonine-protein kinase, active site
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0090060	Wolcott-Rallison syndrome	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements