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homer scaffold protein 2

Summary

Gene Symbol

HOMER2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9455

PubChem

9455

Alliance of Genome Resources

HGNC:17513

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Coiled coil
Cytoplasm
Disease variant
Hearing
Non-syndromic deafness
Reference proteome
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NSB8	Cupidin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
G protein-coupled glutamate receptor signaling pathway	IBA
sensory perception of sound	IMP	25816005
regulation of G protein-coupled receptor signaling pathway	IEA
calcium-mediated signaling	IEA
negative regulation of interleukin-2 production	IMP	18218901

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

behavior [inference]

adult behavior [inference]

behavioral response to cocaine

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of interleukin-2 production [inference]

negative regulation of interleukin-2 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of interleukin-2 production [inference]

negative regulation of interleukin-2 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of interleukin-2 production [inference]

negative regulation of interleukin-2 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of store-operated calcium entry

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of interleukin-2 production [inference]

negative regulation of interleukin-2 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling [inference]

negative regulation of calcineurin-mediated signaling [inference]

negative regulation of calcineurin-NFAT signaling cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

regulation of interleukin-2 production [inference]

negative regulation of interleukin-2 production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-2 production

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	25816005
cytoplasm	IBA
cytosol	TAS
cytosol	IDA
plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

stereocilium tip

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

intracellular organelle

postsynaptic specialization [inference]

postsynaptic density

apical part of cell

Displaying **all 4** entries
GO Term	Evidence Code	PMID
actin binding	IEA
protein binding	IPI	18218901 25416956 32296183
synaptic receptor adaptor activity	IEA
G protein-coupled glutamate receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

G protein-coupled glutamate receptor binding

glutamate receptor binding [inference]

G protein-coupled glutamate receptor binding

cytoskeletal protein binding [inference]

actin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

signaling receptor complex adaptor activity [inference]

synaptic receptor adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

homer

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
G protein-coupled glutamate receptor binding
G protein-coupled glutamate receptor signaling pathway
regulation of store-operated calcium entry

Displaying **all 4** entries
InterPro
Homer family
Homer, EVH1 domain
PH-like domain superfamily
WH1/EVH1 domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110589	autosomal dominant nonsyndromic deafness 68	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 75 in total

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Species	Gene ID	Orthologous MAtrix
Pan paniscus	100991942	PANPA13991
Papio anubis	100999335	PAPAN35792
Saimiri boliviensis boliviensis	101032135	SAIBB03270
Takifugu rubripes	101069532	TAKRU08410
Felis catus	101097400	FELCA13907
Ovis aries	101106114	SHEEP07757
Gorilla gorilla gorilla	101141615	GORGO10624
Oryzias latipes	101156722	ORYLA12209
Tursiops truncatus	101327242	TURTR04731
Mustela putorius furo	101688984	MUSPF08636

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements