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Guidelines

MIRAGE

RAS protein activator like 2

Summary

Gene Symbol

RASAL2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9462

PubChem

9462

Alliance of Genome Resources

HGNC:9874

Annotation

Keyword

Alternative splicing
Coiled coil
GTPase activation
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8Q3SIU1
A8K2P3
Q9UJF2	RAS protein activator-like 2
A0A8Q3SJF6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
response to dietary excess	IEA
signal transduction	TAS	9877179
response to glucose	IEA
gene expression	IEA
multicellular organism growth	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

signal transduction

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

multicellular organismal process [inference]

multicellular organism growth

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

connective tissue development [inference]

adipose tissue development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to dietary excess

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein activation cascade

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein activation cascade

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein maturation [inference]

regulation of protein activation cascade

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein activation cascade

regulation of protein metabolic process [inference]

regulation of protein maturation [inference]

regulation of protein activation cascade

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein maturation [inference]

regulation of protein activation cascade

regulation of cellular process [inference]

signal transduction

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein activation cascade

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 2** entries
GO Term	Evidence Code	PMID
GTPase activator activity	IEA
protein binding	IPI	14743216 18985028 25416956 32296183 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ras GTPase-activating protein

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 8** entries
InterPro
C2 domain superfamily
C2 domain
Disabled homolog 2-interacting protein, C-terminal domain
Pleckstrin homology domain
Ras GTPase-activating domain
Ras GTPase-activating protein, conserved site
Ras GTPase-activating protein
Rho GTPase activation protein

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	8831	SGD:S000001575
Xenopus tropicalis	9462	Xenbase:XB-GENE-5795955
Saccharomyces cerevisiae S288C	64926	SGD:S000001575
Saccharomyces cerevisiae S288C	69601	SGD:S000001575
Mus musculus	226525		MOUSE28232
Saccharomyces cerevisiae S288C	240057	SGD:S000001575
Rattus norvegicus	304893		RATNO07388
Pan troglodytes	457547		PANTR23101
Canis lupus familiaris	480056		CANLF17212
Macaca mulatta	718958		MACMU23025

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025