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phosphate cytidylyltransferase 1B, choline

Summary

Gene Symbol

PCYT1B

Aliases

CCT-beta
CCTbeta
CTB
CTP:phosphocholine cytidylyltransferase-beta
choline-phosphate cytidylyltransferase beta
phosphorylcholine transferase beta

Organism

Homo sapiens (human)

External Links

NCBI Gene

9468

HGNC

8755

KEGG Gene ID

hsa:9468

PubChem

9468

Alliance of Genome Resources

HGNC:8755

Annotation

Keyword

Alternative splicing
Cytoplasm
Endoplasmic reticulum
Nucleotidyltransferase
Phospholipid biosynthesis
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y5K3	CCT-beta CTP:phosphocholine cytidylyltransferase B Phosphorylcholine transferase B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ovarian follicle development	IEA
spermatogenesis	IEA
CDP-choline pathway	IDA	10480912
phosphatidylcholine biosynthetic process	IDA	10480912

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

reproductive process [inference]

developmental process involved in reproduction [inference]

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure development [inference]

ovarian follicle development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	10480912
cytoplasm		9593753
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
choline-phosphate cytidylyltransferase activity	IBA IDA	10480912
phosphatidylcholine binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

cytidylyltransferase activity [inference]

choline-phosphate cytidylyltransferase activity

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylcholine binding

ion binding [inference]

cation binding [inference]

phosphatidylcholine binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00968

Name

choline-phosphate cytidylyltransferase [EC:2.7.7.15]

References

7918629

Rhea

H⁺ + phosphocholine + CTP

diphosphate + CDP-choline

Enzyme

2.7.7.15

PMID

Disease

Disease Ontology

Displaying entries **31 - 40** of 53 in total

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DO ID	Disease Name	Source
DOID:219	colon cancer	DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET DisGeNET
DOID:2349	arteriosclerosis	DisGeNET DisGeNET
DOID:235	colonic benign neoplasm	DisGeNET
DOID:3007	breast ductal carcinoma	DisGeNET
DOID:318	progressive muscular atrophy	DisGeNET
DOID:332	amyotrophic lateral sclerosis	DisGeNET
DOID:3393	coronary artery disease	DisGeNET
DOID:3459	breast carcinoma	DisGeNET
DOID:3571	liver cancer	DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001639
Gene Name: phosphate cytidylyltransferase 1, choline, beta

Ortholog

Displaying entries **31 - 40** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Pan troglodytes	465542		PANTR45676
Pongo abelii	100462209		PONAB37627
Canis lupus familiaris	119868415		CANLF19633
Mustela putorius furo	101688816		MUSPF06236
Felis catus	101095719		FELCA40023
Tursiops truncatus	101318344		TURTR15993
Balaenoptera musculus	118889236		BALMU19000
Loxodonta africana	100671200		LOXAF08516
Equus caballus	100052163		HORSE44459
Sus scrofa	100152643		PIGXX37066

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024