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phosphate cytidylyltransferase 1B, choline

Summary

Gene Symbol

PCYT1B

Aliases

CCT-beta
CCTbeta
CTB
CTP:phosphocholine cytidylyltransferase-beta
choline-phosphate cytidylyltransferase beta
phosphorylcholine transferase beta

Organism

Homo sapiens (human)

External Links

NCBI Gene

9468

HGNC

8755

KEGG Gene ID

hsa:9468

PubChem

9468

Alliance of Genome Resources

HGNC:8755

Annotation

Keyword

Alternative splicing
Cytoplasm
Endoplasmic reticulum
Nucleotidyltransferase
Phospholipid biosynthesis
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y5K3	CCT-beta CTP:phosphocholine cytidylyltransferase B Phosphorylcholine transferase B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ovarian follicle development	IEA
spermatogenesis	IEA
CDP-choline pathway	IDA	10480912
phosphatidylcholine biosynthetic process	IDA	10480912

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

reproductive process [inference]

developmental process involved in reproduction [inference]

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure development [inference]

ovarian follicle development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	10480912
cytoplasm		9593753
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
choline-phosphate cytidylyltransferase activity	IBA IDA	10480912
phosphatidylcholine binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

cytidylyltransferase activity [inference]

choline-phosphate cytidylyltransferase activity

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylcholine binding

ion binding [inference]

cation binding [inference]

phosphatidylcholine binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00968

Name

choline-phosphate cytidylyltransferase [EC:2.7.7.15]

References

7918629

Rhea

H⁺ + phosphocholine + CTP

diphosphate + CDP-choline

Enzyme

2.7.7.15

PMID

Disease

Disease Ontology

Displaying entries **31 - 40** of 53 in total

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DO ID	Disease Name	Source
DOID:219	colon cancer	DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET DisGeNET
DOID:2349	arteriosclerosis	DisGeNET DisGeNET
DOID:235	colonic benign neoplasm	DisGeNET
DOID:3007	breast ductal carcinoma	DisGeNET
DOID:318	progressive muscular atrophy	DisGeNET
DOID:332	amyotrophic lateral sclerosis	DisGeNET
DOID:3393	coronary artery disease	DisGeNET
DOID:3459	breast carcinoma	DisGeNET
DOID:3571	liver cancer	DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001639
Gene Name: phosphate cytidylyltransferase 1, choline, beta

Ortholog

Displaying entry **81 - 81** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Strigops habroptila	115602854		STRHB00356

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Last updated: August 19, 2024