GlyCosmos Portal

Submissions

carbohydrate sulfotransferase 3

Summary

Gene Symbol

CHST3

Aliases

C6ST
C6ST1
chondroitin 6 sulfotransferase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9469

GGDB ID

gg025

HGNC

1971

mRNA

NM_004273

map

10q22.1

Protein

NP_004264

OMIM

603799

KEGG Gene ID

hsa:9469

PubChem

9469

Alliance of Genome Resources

HGNC:1971

Annotation

Keyword

Carbohydrate metabolism
Disease variant
Glycoprotein
Golgi apparatus
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7LGC8	Chondroitin 6-O-sulfotransferase 1 Chondroitin 6-sulfotransferase Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sulfur compound metabolic process	IDA	9883891
chondroitin sulfate biosynthetic process	IBA IDA IMP TAS	15215498 9883891
carbohydrate metabolic process	IEA
T cell homeostasis	IEA
N-acetylglucosamine metabolic process	IBA

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

T cell homeostasis

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

amino sugar metabolic process [inference]

glucosamine-containing compound metabolic process [inference]

N-acetylglucosamine metabolic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

T cell homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

T cell homeostasis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
trans-Golgi network	IBA
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

Displaying **all 3** entries
GO Term	Evidence Code	PMID
chondroitin 6-sulfotransferase activity	IBA IDA TAS	15215498 9883891
proteoglycan sulfotransferase activity	IEA
N-acetylglucosamine 6-O-sulfotransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity [inference]

N-acetylglucosamine 6-O-sulfotransferase activity

chondroitin sulfotransferase activity [inference]

chondroitin 6-sulfotransferase activity

proteoglycan sulfotransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000122863

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg025

Gene Symbol

CHST3

Reactions

Displaying **all 4** entries
Donor	Acceptor	Reference
PAPS	G31119YY	9147050
PAPS	G00058MO	9147050
PAPS	G04218XE	9147050
PAPS	G00055MO	9147050

Displaying **all 3** entries
Donor	Acceptor	Reference
PAPS	G00054MO	9147050
PAPS	G73480MV	10781596
PAPS	G49108TO	10781596

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_445860	NM_053408
Mus musculus	NP_058083	NM_016803

Rhea

RHEA:11108

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

2.8.2.17

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **191** in total

1

2

3

4

5

…

Next ›

Last »
DO ID	Disease Name	Source
DOID:0050429	Hailey-Hailey disease	DisGeNET
DOID:0050657	Bannayan-Riley-Ruvalcaba syndrome	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET
DOID:0050811	congenital adrenal hyperplasia	DisGeNET DisGeNET
DOID:0050813	spondyloepiphyseal dysplasia with congenital joint dislocations	Glyco-Disease Genes Database DisGeNET Alliance of Genome Resources
DOID:0060249	scoliosis	DisGeNET DisGeNET
DOID:0060318	acute promyelocytic leukemia	DisGeNET
DOID:0060462	Desbuquois dysplasia	DisGeNET
DOID:0060467	humeroradial synostosis	DisGeNET
DOID:0060762	restrictive dermopathy	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of **145** in total

1

2

3

4

5

…

Next ›

Last »
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000023	Inguinal hernia
HP:0000160	Narrow mouth
HP:0000175	Cleft palate
HP:0000218	High palate
HP:0000238	Hydrocephalus
HP:0000248	Brachycephaly
HP:0000274	Small face
HP:0000308	Microretrognathia
HP:0000316	Hypertelorism

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:245600	Larsen-like syndrome, B3GAT3 type
OMIM:143095	spondyloepiphyseal dysplasia with congenital joint dislocations
ORPHA:263463	spondyloepiphyseal dysplasia with congenital joint dislocations

PubChem Disease

GHR Health Conditions

CHST3-related skeletal dysplasia

MedGen Diseases

OMIM Phenotypes

SPONDYLOEPIPHYSEAL DYSPLASIA WITH CONGENITAL JOINT DISLOCATIONS; SEDCJD

KEGG Diseases

Spondyloepiphyseal dysplasia with congenital joint dislocations

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 84 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33913	FB:FBgn0031826
Callorhinchus milii	103182392		CALMI02664
Latimeria chalumnae	102357620		LATCH13534
Danio rerio	556800	ZFIN:ZDB-GENE-080204-33
Danio rerio	559721	ZFIN:ZDB-GENE-090312-180
Astyanax mexicanus	103025878		ASTMX21370
Ictalurus punctatus	108273607		ICTPU04502
Electrophorus electricus	113588408		ELEEL41343
Salmo salar	123738507		SALSA01027
Salmo trutta	115181226		SALTR49393

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

PubChem Disease

International Collaboration

Acknowledgements