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Guidelines

MIRAGE

napsin A aspartic peptidase

Summary

Gene Symbol

NAPSA

Organism

Homo sapiens (human)

External Links

NCBI Gene

9476

PubChem

9476

Alliance of Genome Resources

HGNC:13395

Annotation

Keyword

Aspartyl protease
Direct protein sequencing
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Secreted
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O96009	Aspartyl protease 4 Napsin-1 TA01/TA02
M0QXC5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	NAS	9877162
proteolysis	IBA
membrane protein proteolysis	IDA	14766755
surfactant homeostasis	IDA	18216060

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

membrane protein proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

membrane protein proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

membrane protein proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

membrane protein proteolysis

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

chemical homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	18216060
extracellular space	IBA
lysosome	IDA	14766755
lysosome	IBA
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen [inference]

late endosome lumen [inference]

multivesicular body lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

lamellar body [inference]

alveolar lamellar body

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

lamellar body [inference]

alveolar lamellar body

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

lamellar body [inference]

alveolar lamellar body

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endopeptidase activity	IDA	14766755
aspartic-type endopeptidase activity	NAS	9877162
aspartic-type endopeptidase activity	IBA
protein binding	IPI	32296183
peptidase activity	IDA	18216060

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pregnancy-associated glycoprotein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
aspartic-type endopeptidase activity
hydrolase activity
proteolysis

Displaying **all 4** entries
InterPro
Aspartic peptidase A1 family
Aspartic peptidase domain superfamily
Aspartic peptidase, active site
Peptidase family A1 domain

Ortholog

Displaying entries **31 - 40** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ovis aries	101116503		SHEEP05704
Gorilla gorilla gorilla	101132797		GORGO15710
Octodon degus	101583244		OCTDE25046
Jaculus jaculus	101601513		JACJA24639
Ictidomys tridecemlineatus	101977432		ICTTR04388
Chinchilla lanigera	102022026		CHILA23945
Macaca fascicularis	102123120		MACFA18849
Capra hircus	102188526		CAPHI09462
Chlorocebus sabaeus	103235077		CHLSB16068
Ursus maritimus	103657149		URSMA25599

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025