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kinesin family member 23

Summary

Gene Symbol

KIF23

Organism

Homo sapiens (human)

External Links

NCBI Gene

9493

PubChem

9493

Alliance of Genome Resources

HGNC:6392

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Coiled coil
Congenital dyserythropoietic anemia
Cytoskeleton
Disease variant
Isopeptide bond
Microtubule
Mitosis
Motor protein
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q02241	Kinesin-like protein 5 Mitotic kinesin-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
mitotic spindle elongation	TAS	1406973
mitotic cytokinesis	IMP	15843429 16236794
microtubule-based movement	IBA
positive regulation of cytokinesis	IMP	16103226
mitotic spindle midzone assembly	IMP	16103226

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement

spindle elongation [inference]

mitotic spindle elongation

spindle midzone assembly [inference]

mitotic spindle midzone assembly

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

spindle elongation [inference]

mitotic spindle elongation

spindle midzone assembly [inference]

mitotic spindle midzone assembly

mitotic cell cycle process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

spindle midzone assembly [inference]

mitotic spindle midzone assembly

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell division [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

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GO Term	Evidence Code	PMID
nucleus	IDA	11782313 15197175
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

kinesin complex

intracellular protein-containing complex [inference]

centralspindlin complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

midbody

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

Flemming body

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

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GO Term	Evidence Code	PMID
microtubule motor activity	IBA
protein binding	IPI	11782313 14676191 15161933 15197175 15778465 16236794 16431929 18201571 18329369 19468300 20451386 22522702 22580824 22750944 26496610 27528609 28514442 32203420 33961781 35271311 36931259 39251607
ATP binding	IEA
microtubule binding	IDA	11782313
microtubule binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinesin-like protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
cytoskeletal motor activity
microtubule binding
microtubule-based movement
nucleotide binding

Displaying **all 5** entries
InterPro
Kinesin motor domain superfamily
Kinesin motor domain, conserved site
Kinesin motor domain
Kinesin-like protein
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111399	congenital dyserythropoietic anemia type IIIa	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9493	Xenbase:XB-GENE-999865
Danio rerio	30627		DANRE14086
Mus musculus	71819	Xenbase:XB-GENE-999865	MOUSE63066
Rattus norvegicus	315740		RATNO42224
Pan troglodytes	453544		PANTR10677
Canis lupus familiaris	478355		CANLF12650
Bos taurus	515748		BOVIN00539
Macaca mulatta	695229		MACMU42193
Ornithorhynchus anatinus	100085602		ORNAN21727
Taeniopygia guttata	100222140		TAEGU02404

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OrthoDB (Group)

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Acknowledgements