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Guidelines

MIRAGE

peptidase, mitochondrial processing subunit beta

Summary

Gene Symbol

PMPCB

Organism

Homo sapiens (human)

External Links

NCBI Gene

9512

PubChem

9512

Alliance of Genome Resources

HGNC:9119

JoGo

PMPCB

TogoVar

PMPCB

Annotation

Keyword

Direct protein sequencing
Disease variant
Metal-binding
Metalloprotease
Mitochondrion
Neurodegeneration
Proteomics identification
Reference proteome
Transit peptide
Zinc

Proteins

Displaying **all 7** entries
UniProt	Protein Name
O75439	Beta-MPP P-52
Q96CP5	Beta-MPP
A0A9L9PXH0	Beta-MPP
B3KM34	Beta-MPP
A0A9L9PXI7	Beta-MPP
G3V0E4	Beta-MPP
A0A9L9PXG6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein processing involved in protein targeting to mitochondrion	NAS	32443488
protein processing involved in protein targeting to mitochondrion	IDA	22354088
protein processing involved in protein targeting to mitochondrion	IBA
mitochondrial calcium ion transmembrane transport	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing [inference]

protein processing involved in protein targeting to mitochondrion

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing [inference]

protein processing involved in protein targeting to mitochondrion

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing [inference]

protein processing involved in protein targeting to mitochondrion

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing [inference]

protein processing involved in protein targeting to mitochondrion

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing [inference]

protein processing involved in protein targeting to mitochondrion

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing [inference]

protein processing involved in protein targeting to mitochondrion

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing [inference]

protein processing involved in protein targeting to mitochondrion

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing [inference]

protein processing involved in protein targeting to mitochondrion

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

mitochondrial transport [inference]

mitochondrial calcium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	NAS	32443488
mitochondrion	IDA	22354088
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial matrix	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

mitochondrial protein-containing complex [inference]

mitochondrial processing peptidase complex

catalytic complex [inference]

mitochondrial processing peptidase complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	TAS
metalloendopeptidase activity	IDA	22354088
metalloendopeptidase activity	IBA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
metal ion binding
metalloendopeptidase activity
protein processing involved in protein targeting to mitochondrion
proteolysis

Displaying **all 4** entries
InterPro
Metalloenzyme, LuxS/M16 peptidase-like
Peptidase M16, C-terminal
Peptidase M16, N-terminal
Peptidase M16, zinc-binding site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070332	multiple mitochondrial dysfunctions syndrome 6	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025