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Guidelines

MIRAGE

BAG cochaperone 3

Summary

Gene Symbol

BAG3

Organism

Homo sapiens (human)

External Links

NCBI Gene

9531

KEGG Gene ID

PubChem

9531

Alliance of Genome Resources

HGNC:939

Annotation

Keyword

Acetylation
Apoptosis
Cardiomyopathy
Chaperone
Charcot-Marie-Tooth disease
Cytoplasm
Disease variant
Isopeptide bond
Methylation
Myofibrillar myopathy
Neurodegeneration
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O95817	Bcl-2-associated athanogene 3 Bcl-2-binding protein Bis Docking protein CAIR-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
autophagosome assembly	IEA
protein folding	NAS
protein folding	IDA
protein folding	IEA
extrinsic apoptotic signaling pathway via death domain receptors	IDA

GO Hierarchy

biological process

cellular process [inference]

protein folding

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

protein transport along microtubule

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

metabolic process [inference]

catabolic process [inference]

autophagy [inference]

chaperone-mediated autophagy

macromolecule catabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

protein metabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

muscle cell apoptotic process [inference]

striated muscle cell apoptotic process

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

protein transport along microtubule

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

process utilizing autophagic mechanism [inference]

autophagy [inference]

chaperone-mediated autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

inclusion body assembly [inference]

aggresome assembly

organelle assembly [inference]

autophagosome assembly

developmental process [inference]

anatomical structure development [inference]

animal gross anatomical part developmental process [inference]

spinal cord development

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

response to stimulus [inference]

response to stress [inference]

response to heat [inference]

cellular response to heat

cellular response to stress [inference]

cellular response to heat

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

cellular response to heat

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

establishment of localization [inference]

transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

protein transport along microtubule

microtubule-based transport [inference]

transport along microtubule [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

protein transport along microtubule

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

protein transport along microtubule

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein localization to mitochondrion [inference]

negative regulation of protein localization to mitochondrion

negative regulation of protein localization [inference]

negative regulation of protein localization to mitochondrion

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

negative regulation of protein localization [inference]

negative regulation of protein localization to mitochondrion

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of aggrephagy [inference]

positive regulation of aggrephagy

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
stress fiber	IEA
nucleus	IDA
nucleus	IBA
nucleus	IEA
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

protein folding chaperone complex

cellular anatomical structure [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

microtubule organizing center [inference]

ciliary basal body

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
adenyl-nucleotide exchange factor activity	IDA
adenyl-nucleotide exchange factor activity	IBA
protein binding	IPI
protein-macromolecule adaptor activity	IDA
protein-containing complex binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

dynein intermediate chain binding

cell adhesion molecule binding [inference]

cadherin binding

protein-folding chaperone binding

protein-containing complex binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

ATPase regulator activity [inference]

adenyl-nucleotide exchange factor activity

molecular carrier activity [inference]

protein carrier activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080097	myofibrillar myopathy 6	Alliance of Genome Resources
DOID:0110448	dilated cardiomyopathy 1HH	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	29810	MGI:1352493

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026