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MIRAGE
gamma-aminobutyric acid type B receptor subunit 2
Summary
- Gene Symbol
-
- GABBR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Coiled coil
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Epilepsy
- G-protein coupled receptor
- Glycoprotein
- Intellectual disability
- Phosphoprotein
- Postsynaptic cell membrane
- Reference proteome
- Signal
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| chemical synaptic transmission | ||
| synaptic transmission, GABAergic | ||
| neuron-glial cell signaling |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasm | ||
| plasma membrane | ||
| plasma membrane | ||
| G protein-coupled receptor heterodimeric complex | ||
| G protein-coupled receptor heterodimeric complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| transmembrane signaling receptor activity | ||
| G protein-coupled GABA receptor activity | ||
| protein binding | ||
| protein heterodimerization activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| G protein-coupled GABA receptor activity |
| gamma-aminobutyric acid signaling pathway |
| InterPro |
|---|
| GPCR family 3, C-terminal |
| GPCR family 3, GABA-B receptor |
| Periplasmic binding protein-like I |
| Receptor, ligand binding region |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050742 | nicotine dependence | |
| DOID:0080291 | developmental and epileptic encephalopathy 59 | |
| DOID:1574 | alcohol use disorder |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 115578840 | SPAAU22786 | ||
| 115617450 | STRHB14890 | ||
| 116448826 | CORMO07254 | ||
| 117032281 | RHIFE21525 | ||
| 118896601 | BALMU13597 |
